α2b-肾上腺素能受体基因缺失变体调节 COMT val(158)met 多态性对情景记忆表现的影响。
Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance.
机构信息
Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King's College London, United Kingdom.
出版信息
Eur Neuropsychopharmacol. 2010 Apr;20(4):272-5. doi: 10.1016/j.euroneuro.2009.12.007. Epub 2010 Jan 27.
The COMT val(158) variant has been associated with impaired cognitive function compared to the met(158) variant yet gene-gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to met(158) carriers.
COMT val(158) 变体与 met(158) 变体相比，与认知功能受损相关，但基因-基因相互作用尚未得到很好的描述。在这项研究中，我们证明了这种 COMT 多态性与 ADRA2B 的缺失变体之间存在相互作用，ADRA2B 基因编码了与情景记忆表现相关的α2b-肾上腺素能受体。具体来说，携带 ADRA2B 缺失消除了 COMT val(158) 纯合子携带者与 met(158) 携带者相比相对记忆损伤。
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