Division of Clinical Medicine, Brighton and Sussex Medical School, Falmer, Brighton BN1 9RR, United Kingdom, Institute of Psychiatry, King's College London, King's Health Partners, London SE5 8AF, United Kingdom, and School of Psychology, University of Sussex, Falmer, Brighton BN1 9RR, United Kingdom.
J Neurosci. 2013 Oct 23;33(43):17023-8. doi: 10.1523/JNEUROSCI.2124-13.2013.
Evidence suggests that emotional memory plays a role in the pathophysiology of depression/anxiety disorders. Noradrenaline crucially modulates emotional memory. Genetic variants involved in noradrenergic signaling contribute to individual differences in emotional memory and vulnerability to psychopathology. A functional deletion polymorphism in the α-2B adrenoceptor gene (ADRA2B) has been linked to emotional memory and post-traumatic stress disorder. The noradrenaline reuptake inhibitor reboxetine attenuates enhanced memory for negative stimuli in healthy and depressed individuals. We examined whether the effect of reboxetine on emotional memory in healthy individuals would be moderated by ADRA2B genotype. ADRA2B deletion carriers demonstrated enhanced emotional memory for negative stimuli compared with deletion noncarriers, consistent with prior studies. Reboxetine attenuated enhanced memory for negative stimuli in deletion noncarriers but had no significant effect in deletion carriers. This is the first demonstration of genetic variation influencing antidepressant drug effects on emotional processing in healthy humans.
有证据表明，情绪记忆在抑郁/焦虑障碍的病理生理学中起作用。去甲肾上腺素对情绪记忆起着至关重要的调节作用。参与去甲肾上腺素信号传递的遗传变异导致个体在情绪记忆方面存在差异，并易患精神病理学。α-2B 肾上腺素能受体基因（ADRA2B）中的功能性缺失多态性与情绪记忆和创伤后应激障碍有关。去甲肾上腺素再摄取抑制剂瑞波西汀可减轻健康个体和抑郁个体对负面刺激的记忆增强。我们研究了 ADRA2B 基因型是否会调节瑞波西汀对健康个体情绪记忆的影响。ADRA2B 缺失携带者对负面刺激的情绪记忆增强，与先前的研究一致。瑞波西汀可减轻非缺失携带者对负面刺激的记忆增强，但对缺失携带者无显著影响。这是首次证明遗传变异影响抗抑郁药对健康人群情绪处理的作用。
