[在禽胚外植体悬浮液中商业化培养的伪狂犬病病毒的繁殖、形态发生及免疫生物学特性]
[Reproduction, morphogenesis and immunobiological properties of Aujeszky's disease virus commercially cultured in a suspension of poultry embryo explants].
作者信息
Nochevnyĭ V T, Blekherman B E, Osidze D F, Khor'kov I A, Kuznetsov P P
出版信息
Vopr Virusol. 1977 Sep-Oct(5):591-7.
The results of the study of reproduction, morphogenesis, and immunogenic properties of Aujeszky's disease virus (ADV) cultivated on an industrial scale in chick, duck and quail embryo explant suspensions are presented. A method for production of vaccine and virulent ADV strains with the activity of at least 7.5 log TCD50/ML in tanks of 5, 50, and 100 1 capacity was developed. A relationship between virion morphology and duration of cultivation was established. For ADV cultivated for 70 hours, a direct relationship between infectivity and immunogenicity was demonstrated.
本文介绍了在鸡、鸭和鹌鹑胚胎外植体悬浮液中大规模培养的奥耶斯基氏病病毒（ADV）的繁殖、形态发生和免疫原性特性的研究结果。开发了一种在容量为5升、50升和100升的罐中生产活性至少为7.5 log TCD50/ML的疫苗和强毒ADV毒株的方法。建立了病毒粒子形态与培养持续时间之间的关系。对于培养70小时的ADV，证明了感染性和免疫原性之间存在直接关系。
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