Department of Psychiatry, Odense University Hospital, Denmark.
Dement Geriatr Cogn Disord. 2010;29(1):61-7. doi: 10.1159/000265553. Epub 2010 Jan 27.
BACKGROUND/AIMS: To examine the mortality of very mildly to severely demented persons compared to nondemented persons.
Participants in a randomly drawn population-based cohort study on dementia were followed for 14 years from 1992 to 2006. Participants were examined at baseline (3,065 nondemented and 234 prevalent demented), after 2 years (2,286 nondemented and 145 incident demented) and again after 5 years (1,669 nondemented and 124 new cases of dementia). Causes of death were ascertained in 884 nondemented and 286 demented participants. Survival for demented compared to nondemented persons was analyzed with the Cox proportional hazards model with time-dependent covariates adjusted for gender and age.
The hazard ratio of death (95% confidence interval) increased from 1.82 (1.55-2.14) for the very mildly demented to 9.52 (6.60-13.74) for the severely demented subjects. The demented participants died significantly more often of neurological causes other than dementia and of pneumonia than the nondemented participants. No other significant differences in causes of death were found.
Dementia increased the risk of death. Even in the very early stages of dementia the risk of death was increased.
背景/目的：检查轻度至重度痴呆患者与非痴呆患者的死亡率。
对一项基于人群的痴呆症随机抽样队列研究中的参与者进行了 14 年的随访，从 1992 年到 2006 年。在基线时（3065 名非痴呆患者和 234 名现患痴呆患者）、2 年后（2286 名非痴呆患者和 145 名新发痴呆患者）以及 5 年后（1669 名非痴呆患者和 124 名新发痴呆患者）对参与者进行了检查。在 884 名非痴呆患者和 286 名痴呆患者中确定了死因。使用 Cox 比例风险模型分析痴呆与非痴呆患者的生存情况，该模型调整了性别和年龄的时间依赖性协变量。
死亡风险比（95%置信区间）从轻度痴呆患者的 1.82（1.55-2.14）增加到重度痴呆患者的 9.52（6.60-13.74）。痴呆患者死于非痴呆原因的神经系统疾病和肺炎的比例明显高于非痴呆患者。未发现其他死因的显著差异。
痴呆症增加了死亡风险。即使在痴呆症的早期阶段，死亡风险也会增加。
