Hötte Sebastian Dirk, Lankers Daniel, Kissler Sebastian, Freyberger Harald-Jürgen, Schröder Stefan Georg
Ernst-Moritz-Arndt-Universität Greifswald und LWL-Universitätsklinik Bochum der Ruhr-Universität Bochum.
Psychiatr Prax. 2010 Mar;37(2):78-83. doi: 10.1055/s-0029-1223473. Epub 2010 Feb 24.
Evaluation of the predictive power of the Mini-Mental State Examination (MMSE) for survival analyses of dementia patients.
In an 8-year follow-up study for 145 dementia outpatients the survival and relative death risks (hazard ratios) were calculated with Kaplan Meier and Cox-regression analyses.
Following Cox-regression the relative death risk increases by 36.2 % per severity level of dementia (mild / moderate / severe), p = 0.023. Per single MMSE point lost, the relative death risk rises by 4.1 % (p = 0.005). Kaplan Meier analysis supports the result.
MMSE scores may in fact be used for dementia survival prognoses in counseling family and professional caregivers of dementia patients, but also for socioeconomic management of the increasing dementia burden for society.
评估简易精神状态检查表（MMSE）对痴呆患者生存分析的预测能力。
在一项针对145名痴呆门诊患者的8年随访研究中，采用Kaplan Meier和Cox回归分析计算生存率和相对死亡风险（风险比）。
经Cox回归分析，痴呆严重程度每增加一级（轻度/中度/重度），相对死亡风险增加36.2%，p = 0.023。MMSE每降低一分，相对死亡风险上升4.1%（p = 0.005）。Kaplan Meier分析支持该结果。
MMSE评分实际上可用于为痴呆患者的家庭和专业护理人员提供咨询时进行痴呆生存预后评估，也可用于对社会日益加重的痴呆负担进行社会经济管理。
