Guehne Uta, Luck Tobias, Busse Anja, Angermeyer Matthias C, Riedel-Heller Steffi G
Leipzig Longitudinal Study of the Aged (LEILA75+), Department of Psychiatry, University of Leipzig, Leipzig, Germany.
Neuroepidemiology. 2007;29(3-4):226-34. doi: 10.1159/000112479. Epub 2007 Dec 13.
This study aimed to investigate whether mortality is higher for individuals suffering from Mild Cognitive Impairment (MCI).
A community sample of 1,045 dementia-free individuals aged 75 years and over was examined using neuropsychological tests over a 4.5-year period. Data were analyzed with the Cox proportional hazards model after having been adjusted for age, gender, and incident dementia.
Association between MCI and mortality was examined subject to varied diagnostic criteria of MCI. We found an increased risk of death that was about 1.5 times higher for individuals with MCI when a cognitive performance of more than 1.5 standard deviation below the mean of age- and education-matched controls was required and the criterion of a cognitive complaint was excluded. Males were at about a 40% increased risk of death. Risk also increased with age by about 8% per year. Incident dementia showed a significant influence on mortality only if it became manifest by 1.5 years after the baseline measurement (follow-up 1).
MCI is associated with increased mortality when certain diagnostic criteria are applied.
本研究旨在调查轻度认知障碍（MCI）患者的死亡率是否更高。
对1045名年龄在75岁及以上且无痴呆症的社区样本进行了为期4.5年的神经心理学测试。在对年龄、性别和新发痴呆症进行调整后，使用Cox比例风险模型对数据进行分析。
根据MCI的不同诊断标准，研究了MCI与死亡率之间的关联。我们发现，当要求认知表现低于年龄和教育程度匹配对照组平均值1.5个标准差以上且排除认知主诉标准时，MCI患者的死亡风险增加了约1.5倍。男性的死亡风险增加了约40%。风险也随年龄增长而增加，每年约增加8%。仅当新发痴呆症在基线测量后1.5年（随访1）出现时，才对死亡率有显著影响。
应用某些诊断标准时，MCI与死亡率增加相关。
