Department of Nutrition Management, Minami Kyushu University, Miyazaki, Japan.
Obesity (Silver Spring). 2010 Sep;18(9):1871-4. doi: 10.1038/oby.2009.507. Epub 2010 Jan 28.
Pentraxin 3 (PTX3) is an acute-phase protein that shares structural homology with C-reactive protein (CRP). PTX3 is produced in macrophages, endothelial cells, and adipocytes in response to inflammatory stimuli, whereas hepatocytes are the main source of CRP. Because obesity and metabolic syndrome (MetS) are considered chronic inflammatory states, PTX3 might be involved in the pathogenesis of obesity and MetS as well as CRP. Levels of CRP correlated positively with body weight, BMI, waist circumference (WC), fasting plasma glucose and interleukin (IL)-6, and negatively with high-density lipoprotein cholesterol and adiponectin in healthy males. In contrast, PTX3 correlated positively with adiponectin, and negatively with body weight, BMI, WC, and triglyceride. Plasma CRP significantly increased, whereas plasma PTX3 significantly decreased with increasing BMI. Plasma CRP and PTX3 levels were significantly higher and lower, respectively, in individuals who had more than one MetS component compared with those who had none. In conclusion, PTX3 and CRP antagonistically participate in the development of obesity or MetS.
五聚素 3（PTX3）是一种急性期蛋白，与 C 反应蛋白（CRP）具有结构同源性。PTX3 由巨噬细胞、内皮细胞和脂肪细胞在炎症刺激下产生，而肝细胞是 CRP 的主要来源。由于肥胖和代谢综合征（MetS）被认为是慢性炎症状态，PTX3 可能参与肥胖和 MetS 以及 CRP 的发病机制。在健康男性中，CRP 水平与体重、BMI、腰围（WC）、空腹血糖和白细胞介素（IL）-6 呈正相关，与高密度脂蛋白胆固醇和脂联素呈负相关。相反，PTX3 与脂联素呈正相关，与体重、BMI、WC 和甘油三酯呈负相关。随着 BMI 的增加，血浆 CRP 显著增加，而血浆 PTX3 显著降低。与没有任何 MetS 成分的个体相比，具有一个以上 MetS 成分的个体的血浆 CRP 和 PTX3 水平分别显著升高和降低。总之，PTX3 和 CRP 拮抗参与肥胖或 MetS 的发展。
