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ON012380, a putative BCR-ABL kinase inhibitor with a unique mechanism of action in imatinib-resistant cells.

作者信息

Wu J, Meng F, Ying Y, Peng Z, Daniels L, Bornmann W G, Quintás-Cardama A, Roulston D, Talpaz M, Peterson L F, Donato N J

出版信息

Leukemia. 2010 Apr;24(4):869-72. doi: 10.1038/leu.2009.300. Epub 2010 Jan 28.

Abstract
摘要

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本文引用的文献

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Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase.
J Natl Cancer Inst. 2008 Jul 2;100(13):926-39. doi: 10.1093/jnci/djn188. Epub 2008 Jun 24.
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Metabolism and disposition of dasatinib after oral administration to humans.
Drug Metab Dispos. 2008 Jul;36(7):1357-64. doi: 10.1124/dmd.107.018267. Epub 2008 Apr 17.
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Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells.
Blood. 2007 Apr 15;109(8):3470-8. doi: 10.1182/blood-2006-02-005579. Epub 2007 Jan 3.
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A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance.
Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1992-7. doi: 10.1073/pnas.0408283102. Epub 2005 Jan 27.

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