U.O. Radiodiagnostica e Radioterapia Oncologica, AOU Policlinico "G. Rodolico"-Catania, Via Santa Sofia 78-95125-Catania, Italy.
J Oncol. 2009;2009:247873. doi: 10.1155/2009/247873. Epub 2009 Dec 30.
Medulloblastoma is a rare tumor in central nervous system, with an even rarer occurrence in adulthood. The management of a recurrent disease is a medical challenge; chemotherapy has been used as the treatment of choice, while reirradiation has been employed in selected cases. We report the case of a 51-year-old man with recurrent medulloblastoma. He was treated with local reirradiation, chemotherapy, and antiangiogenic drug, with the latter giving the longer progression-free interval. The aim of this report is to show that recurrent medulloblastoma in adults can be approached with a multimodality treatment and that antiangiogenic therapy should have a role in the management of this disease.
髓母细胞瘤是一种罕见的中枢神经系统肿瘤，在成年人中更为罕见。复发性疾病的治疗是一个医学挑战；化疗已被用作首选治疗方法，而在选定的情况下则采用再放疗。我们报告了一例 51 岁男性复发性髓母细胞瘤的病例。他接受了局部再放疗、化疗和抗血管生成药物治疗，后者使无进展间隔时间更长。本报告的目的是表明成人复发性髓母细胞瘤可以采用多模式治疗方法，并且抗血管生成治疗应该在该疾病的治疗中发挥作用。
