Chuah J H, Kim D S, Allen C, Hollis L
Department of Otolaryngology and Head and Neck Surgery, Worcestershire Royal Hospital, Worcester WR5 1DD, UK.
Int J Otolaryngol. 2009;2009:871567. doi: 10.1155/2009/871567. Epub 2009 Mar 16.
Objective. We reported a very rare case of metastatic Crohn's disease involving the retro-auricular region. Method. A case report and a review of literature concerning metastatic Crohn's disease. Results. Metastatic Crohn's disease is an uncommon extraintestinal cutaneous manifestation of Crohn's disease and a very rare case involving the retro-auricular region is reported here. Given the limited existing literature little is known about this condition. The skin lesions appear to have a predilection for the lower trunk and genitalia regions. There is no clear association with the severity of Crohn's disease and in some cases, the cutaneous lesions predate the onset of gastrointestinal Crohn's disease. Treatment with immune-modulating medications together with the antitumour necrosis factor monoclonal antibody therapy appears to offer the best chance of remission. Conclusion. By reporting this interesting and rare condition we also hope to highlight the importance of considering underlying chronic systemic disorders, such as Crohn's disease, when presented with skin lesions resistant to simple local treatments.
目的。我们报告了一例非常罕见的转移性克罗恩病累及耳后区域的病例。方法。病例报告及关于转移性克罗恩病的文献综述。结果。转移性克罗恩病是克罗恩病一种不常见的肠外皮肤表现,本文报告了一例累及耳后区域的非常罕见的病例。鉴于现有文献有限,对此病症了解甚少。皮肤病变似乎好发于下躯干和生殖器区域。它与克罗恩病的严重程度没有明确关联,在某些情况下,皮肤病变早于胃肠道克罗恩病的发病。免疫调节药物联合抗肿瘤坏死因子单克隆抗体治疗似乎提供了最佳的缓解机会。结论。通过报告这一有趣且罕见的病症,我们也希望强调在面对对简单局部治疗有抵抗的皮肤病变时,考虑潜在慢性全身性疾病(如克罗恩病)的重要性。