Schneider Samantha L, Foster Katherine, Patel Devika, Shwayder Tor
Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.
Lakeshore Dermatology, Grand Rapids, MI, USA.
Pediatr Dermatol. 2018 Sep;35(5):566-574. doi: 10.1111/pde.13565. Epub 2018 Jun 28.
Metastatic Crohn's disease is a rare cutaneous complication of primary Crohn's disease. It is a granulomatous inflammatory process, similar to the pathogenic mechanism of Crohn's disease, that occurs in sites discontiguous from the gastrointestinal tract. Metastatic Crohn's disease can precede the development of Crohn's disease by months to years, and children are more likely to present with metastatic Crohn's disease in the absence of gastrointestinal symptoms. Given that approximately 30% of individuals with Crohn's disease present in childhood, early recognition of extraintestinal manifestations of Crohn's disease such as metastatic Crohn's disease can aid in timely diagnosis and management of bowel disease. We present data from two pediatric cases of metastatic Crohn's disease recently seen at our institution in addition to the 61 reported cases of pediatric metastatic Crohn's disease in the literature. This review article will focus on the epidemiology, pathogenesis, clinical features, and histology of and treatment options for pediatric metastatic Crohn's disease.
转移性克罗恩病是原发性克罗恩病一种罕见的皮肤并发症。它是一种肉芽肿性炎症过程，类似于克罗恩病的发病机制，发生于与胃肠道不连续的部位。转移性克罗恩病可在克罗恩病发生前数月至数年出现，且儿童在无胃肠道症状时更易出现转移性克罗恩病。鉴于约30%的克罗恩病患者在儿童期发病，早期识别克罗恩病的肠外表现如转移性克罗恩病有助于及时诊断和治疗肠道疾病。除了文献中报道的61例儿童转移性克罗恩病病例外，我们还展示了最近在我们机构看到的两例儿童转移性克罗恩病病例的数据。这篇综述文章将重点关注儿童转移性克罗恩病的流行病学、发病机制、临床特征、组织学及治疗选择。
