Natural Products Chemistry Division, North-East Institute of Science & Technology, Assam, Jorhat-785006, India.
Chem Soc Rev. 2010 Feb;39(2):435-54. doi: 10.1039/b816679j. Epub 2009 Aug 24.
In this tutorial review, an effort towards presentation of a comprehensive account of the recent developments on various kinds of artemisinin derivatives including artemisinin dimers, trimers and tetramers has been made and their efficacy towards malaria parasites and different cancer cells lines was compared with that of artemisinins, and various other anti-malarial and anti-cancer drugs. It is expected that this review will provide first-hand information on artemisinin chemistry to organic/medicinal chemists, and pharmacologists working on anticancer and anti-malarial drug development.
在本教程综述中，我们努力全面介绍各种青蒿素衍生物的最新发展情况，包括青蒿素二聚体、三聚体和四聚体，并将其对疟原虫和不同癌细胞系的疗效与青蒿素以及其他各种抗疟药和抗癌药进行了比较。我们希望本综述能为从事抗癌和抗疟药物开发的有机/药物化学家以及药理学家提供有关青蒿素化学的第一手信息。
