Landolt A M, Zachmann M
Neurosurgery Section, University of Zürich, Switzerland.
Neurosurgery. 1991 Mar;28(3):410-5. doi: 10.1097/00006123-199103000-00012.
Fourteen patients undergoing transsphenoidal extirpation of craniopharyngiomas or Rathke's cysts underwent endocrinological evaluation before and after surgery. One patient died during the procedure because of uncontrollable arterial bleeding. The other patients were followed for up to 16 years (average, 8.5 years). One patient had recurrence of tumor 12 years after surgery. Another patient, the only one operated on because of a recurrent craniopharyngioma after previous radiation therapy, died 2 years after the transsphenoidal operation. No patient recovered pituitary functions that had been lost before surgery. One patient, who had an isolated growth hormone deficiency, and another, who had panhypopituitarism with sustained antidiuretic hormone secretion, had no change postoperatively from their preoperative endocrine status. The other 11 patients lost pituitary function and required pharmacological replacement of one to four pituitary hormones.
14例接受颅咽管瘤或拉克氏囊肿经蝶窦切除术的患者在手术前后接受了内分泌评估。1例患者在手术过程中因无法控制的动脉出血死亡。其他患者随访长达16年（平均8.5年）。1例患者术后12年肿瘤复发。另1例患者是唯一因先前放疗后复发性颅咽管瘤而接受手术的，经蝶窦手术后2年死亡。没有患者恢复术前已丧失的垂体功能。1例单纯生长激素缺乏患者和另1例全垂体功能减退伴持续性抗利尿激素分泌患者术后内分泌状态与术前无变化。其他11例患者丧失了垂体功能，需要药物替代一至四种垂体激素。
