Jing Cai-xia, Yang Jia-zhou, Ai Qing-yan, Miao Nai-zhou, Zhao Yu-feng, Wang Yan-mei
Department of Parasitology, West China School of Preclinical and Forensic Medicine, Sichuan University, Cheng-du, Sichuan 610041, China.
Zhonghua Nan Ke Xue. 2009 Oct;15(10):932-6.
The GATA family proteins are a group of zinc finger transcription factors that are expressed in human and mammalian animals and play an important role in mammalian organ morphogenesis, cell proliferation and sex differentiation. GATA-4 and GATA-6 have been identified in the ovaries and testes of humans, mice, pigs and chickens. GATA-4 contributes to fetal male gonadal development by regulating the genes that mediate Müllerian duct regression and the onset of testosterone production. GATA-4 and GATA-6 are localized in and regulate the function of the ovarian and testicular somatic cells of fetal mice, especially granulosa cells, thecal cells, Sertoli cells and Leydig cells. GATA-4 is also present in the germ cells of fetal and prepubertal mice.
GATA家族蛋白是一类锌指转录因子，在人类和哺乳动物中表达，在哺乳动物器官形态发生、细胞增殖和性别分化中发挥重要作用。GATA-4和GATA-6已在人类、小鼠、猪和鸡的卵巢和睾丸中被鉴定出来。GATA-4通过调节介导苗勒管退化和睾酮产生起始的基因，促进胎儿雄性性腺发育。GATA-4和GATA-6定位于胎儿小鼠的卵巢和睾丸体细胞中并调节其功能，尤其是颗粒细胞、卵泡膜细胞、支持细胞和间质细胞。GATA-4也存在于胎儿和青春期前小鼠的生殖细胞中。
