Kirana H, Agrawal S S, Srinivasan B P
Delhi Institute of Pharmaceutical Sciences and Research, Sector-III, Pushp Vihar, New Delhi 110 017, India.
Indian J Exp Biol. 2009 Oct;47(10):822-6.
One of the major etiologies in pathogenesis of type 2 diabetes especially complications is oxidative stress. Aqueous extract of Ficus religiosa at a dose of 100 and 200 mg/kg orally decreased the fasting blood glucose in streptozotocin induced type 2 diabetic rats. The drug had enzyme induction effect with respect to catalase (CAT) and glutathione peroxidase (GSH-Px) activity, however decreased the exaggerated activity of superoxide dismutase (SOD) in type 2 diabetic rats. F. religiosa modulated the enzymes of antioxidant defence system to combat oxidative stress. As a result, glutathione (GSH-reduced form) was restored and inhibited the formation of malondialdehyde. Drug at higher dose (200 mg/kg) had more pronounced effect. F. religiosa, a rasayana group of plant drug having anti-diabetic activity along with antioxidant potential was beneficial in treatment of type 2 diabetes.
2型糖尿病发病机制尤其是并发症的主要病因之一是氧化应激。菩提树水提取物以100和200mg/kg的剂量口服可降低链脲佐菌素诱导的2型糖尿病大鼠的空腹血糖。该药物对过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）活性具有酶诱导作用，但降低了2型糖尿病大鼠中超氧化物歧化酶（SOD）的过度活性。菩提树调节抗氧化防御系统的酶以对抗氧化应激。结果，谷胱甘肽（还原型GSH）得以恢复并抑制了丙二醛的形成。较高剂量（200mg/kg）的药物具有更显著的效果。菩提树是一种具有抗糖尿病活性和抗氧化潜力的rasayana类植物药，对2型糖尿病的治疗有益。
