Vijayakumar M, Govindarajan R, Rao G M M, Rao Ch V, Shirwaikar A, Mehrotra S, Pushpangadan P
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226 001, Uttar Pradesh, India.
J Ethnopharmacol. 2006 Apr 6;104(3):356-61. doi: 10.1016/j.jep.2005.09.030. Epub 2005 Nov 9.
Hygrophila auriculata (K. Schum.) Heine (Family: Acanthaceae) is a wild herb widely used in 'Ayurveda' as 'Rasayana' drug for treatment of various disorders. Treatment of diabetic rats with aerial parts of Hygrophila auriculata extract (HAEt, 100 and 250 mg/kg body weight) for 3 weeks showed significant reduction in blood glucose, thiobarbituric acid reactive substances (TBARS) and hydroperoxide in both liver and kidney. The treatment with HAEt significantly increased the glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT) in the drug-treated group, which is comparable to the control group. HAEt and glibenclamide-treated rats also showed decreased lipid peroxidation that is associated with increased activity of superoxide dismutase (SOD) and catalase. The ability of HAEt on tissue lipid peroxidation and antioxidant status in diabetic animals has not been studied before. The result of this study thus shows that HAEt possesses significant antidiabetic activity along with potent antioxidant potential in diabetic conditions.
耳叶水蓑衣（学名：Hygrophila auriculata (K. Schum.) Heine，爵床科）是一种野生草本植物，在阿育吠陀医学中被广泛用作“rasayana”药物来治疗各种疾病。用耳叶水蓑衣提取物（HAEt，100和250毫克/千克体重）的地上部分对糖尿病大鼠进行为期3周的治疗后，其血糖、硫代巴比妥酸反应性物质（TBARS）以及肝脏和肾脏中的氢过氧化物均显著降低。在药物治疗组中，用HAEt治疗显著增加了谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽S-转移酶（GST）和过氧化氢酶（CAT）的水平，与对照组相当。用HAEt和格列本脲治疗的大鼠还表现出脂质过氧化减少，这与超氧化物歧化酶（SOD）和过氧化氢酶活性增加有关。此前尚未研究过HAEt对糖尿病动物组织脂质过氧化和抗氧化状态的影响。因此，本研究结果表明，HAEt在糖尿病状态下具有显著的抗糖尿病活性以及强大的抗氧化潜力。
