Asdaq Syed Mohammed Basheeruddin, Inamdar Mohammed Naseeruddin
Department of Pharmacology, Krupanidhi College of Pharmacy, Bangalore - 560 035.
Indian J Physiol Pharmacol. 2009 Apr-Jun;53(2):127-36.
The purpose of current study was to evaluate the influence of hydrochlorothiazide (HCTZ) on protective effects of garlic homogenate (GH) in rats subjected to myocardial damage induced by ischemia-reperfusion (IRI) and isoproterenol (ISO). Female Wistar albino rats were treated with GH at three different doses of 125; 250 and 500 mg/kg orally for 30 days and HCTZ (10 mg/kg, p.o.) was incorporated in the interactive groups during the last seven days of GH treatment. At the end of treatment, animals were subjected to IRI or ISO induced myocardial damage in their respective models. The GH 250 mg/kg was found to dislodge the effect of ISO and IRI on superoxide dismutase & catalase and retained the activities of LDH and CK-MB. Adding HCTZ improved biochemical, antioxidant and histological status of myocardium during myocardial damage. Since no toxic effects were observed, HCTZ may safely be used to improve GH therapy.
本研究的目的是评估氢氯噻嗪（HCTZ）对大蒜匀浆（GH）在遭受缺血再灌注（IRI）和异丙肾上腺素（ISO）诱导的心肌损伤大鼠中的保护作用的影响。雌性Wistar白化大鼠分别以125、250和500mg/kg这三种不同剂量口服GH，持续30天，在GH治疗的最后七天，交互组加入HCTZ（10mg/kg，口服）。治疗结束时，动物在各自模型中遭受IRI或ISO诱导的心肌损伤。发现250mg/kg的GH消除了ISO和IRI对超氧化物歧化酶和过氧化氢酶的影响，并保留了乳酸脱氢酶和肌酸激酶同工酶的活性。添加HCTZ可改善心肌损伤期间心肌的生化、抗氧化和组织学状态。由于未观察到毒性作用，HCTZ可安全用于改善GH治疗。
