2 型糖尿病患者及健康人群血清铁蛋白与胰岛素抵抗的炎症标志物的关系。
Relationship between serum ferritin and inflammatory biomarkers with insulin resistance in a Persian population with type 2 diabetes and healthy people.
机构信息
Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Int J Food Sci Nutr. 2010 May;61(3):316-23. doi: 10.3109/09637480903555150.
BACKGROUND
The correlation between body iron stores and inflammation with insulin resistance in type 2 diabetes is not thoroughly investigated, especially in the Persian population.
METHODS
A cross-sectional study was designed in Tehran, Iran. Fifty-four people with type 2 diabetes and 53 matched healthy participants were included. Serum ferritin, total iron binding capacity, insulin resistance, C-reactive protein and tumor necrosis factor-alpha were measured in both groups.
RESULTS
Diabetic patients had higher insulin resistance, hemoglobin A(1)C and serum ferritin. Significant positive correlations were observed between insulin resistance with serum ferritin and tumor necrosis factor-alpha and between serum ferritin and tumor necrosis factor-alpha in diabetic patients.
CONCLUSIONS
Inter-relationship between insulin resistance, serum ferritin and TNF-alpha was found in type 2 diabetic patients. Serum iron even in the normal range had positive correlation with insulin resistance. It may be because the normal ranges determined for serum ferritin are too wide and the criteria for iron overload are too high.
背景
2 型糖尿病患者体内铁储存与炎症和胰岛素抵抗之间的相关性尚未得到充分研究，特别是在波斯人群中。
方法
本研究为在伊朗德黑兰进行的横断面研究。共纳入 54 例 2 型糖尿病患者和 53 例匹配的健康对照者。分别测量两组人群的血清铁蛋白、总铁结合力、胰岛素抵抗、C 反应蛋白和肿瘤坏死因子-α。
结果
糖尿病患者的胰岛素抵抗、糖化血红蛋白和血清铁蛋白水平更高。在糖尿病患者中，胰岛素抵抗与血清铁蛋白和肿瘤坏死因子-α之间，以及血清铁蛋白与肿瘤坏死因子-α之间均存在显著正相关。
结论
2 型糖尿病患者中存在胰岛素抵抗、血清铁蛋白和 TNF-α 之间的相互关系。即使在正常范围内的血清铁也与胰岛素抵抗呈正相关。这可能是因为血清铁蛋白的正常范围确定得太宽，铁过载的标准定得太高。
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