Department of Golden-Ager Industry Management, Chaoyang University of Technology, Taichung, 413, Taiwan.
Department of Psychology, Chung Shan Medical University, Taichung, 402, Taiwan.
Sci Rep. 2023 Nov 18;13(1):20207. doi: 10.1038/s41598-023-47678-5.
This study explored the association between ferritin with hematologic, liver functional, and metabolic parameters in older diabetic patients. A total of 210 diabetic patients aged 65 or older were classified into four groups according to the reference range of serum ferritin. Demographic variables and health-related lifestyle factors were obtained through the utilization of a standardized questionnaire. Anthropometric measures, blood pressure, hematology test, and biochemical assessment were also performed. Among all patients, 29.5% had anemia. The percentage of anemia in groups low ferritin (< 40 μg/L), lower side within the reference range (40-120 μg/L), higher side within the reference range (121-200 μg/L), and high ferritin levels (> 200 μg/L) were 50.0, 27.7, 20.5, and 24.2% (P = 0.025), respectively. Low ferritin levels had a higher risk of anemia and a high red blood cell distribution width (RDW). High ferritin levels were associated with a higher risk of high glutamate pyruvate transaminase, obesity, high fasting blood glucose (FBG), and high postprandial blood glucose. The higher side within the reference range of ferritin also showed a higher risk of high FBG and high glycated hemoglobin. Nevertheless, there was no significant association between ferritin and inflammation marker, serum lipids or blood pressure. Overall, ferritin demonstrates a dual nature in older diabetic patients: low ferritin levels are linked to anemia or elevated RDW, while high levels are linked to obesity, increased liver enzymes, and worse glycemia control.
本研究探讨了铁蛋白与老年糖尿病患者血液学、肝功能和代谢参数之间的关系。将 210 名年龄在 65 岁或以上的糖尿病患者根据血清铁蛋白的参考范围分为四组。通过使用标准化问卷获得人口统计学变量和与健康相关的生活方式因素。还进行了人体测量学测量、血压、血液学检查和生化评估。在所有患者中，29.5%有贫血。铁蛋白水平低(<40μg/L)、参考范围低值(40-120μg/L)、参考范围高值(121-200μg/L)和铁蛋白水平高(>200μg/L)的贫血发生率分别为 50.0%、27.7%、20.5%和 24.2%(P=0.025)。低铁蛋白水平与贫血和高红细胞分布宽度(RDW)的风险增加有关。高铁蛋白水平与高谷氨酸丙酮酸转氨酶、肥胖、高空腹血糖(FBG)和高餐后血糖的风险增加有关。铁蛋白参考范围的高值也与高 FBG 和高糖化血红蛋白的风险增加有关。然而，铁蛋白与炎症标志物、血清脂质或血压之间没有显著关联。总的来说，铁蛋白在老年糖尿病患者中表现出双重性质：低铁蛋白水平与贫血或 RDW 升高有关，而高水平与肥胖、肝酶升高和血糖控制恶化有关。
