Canturk Zeynep, Cetinarslan Berrin, Tarkun Ilhan, Canturk Nuh Zafer
Department of Endocrinology and Metabolism, Kocaeli University, Medical School, Derince, Kocaeli, Turkey.
Endocr Res. 2003 Aug;29(3):299-306. doi: 10.1081/erc-120025037.
Serum ferritin level is related to body iron stores and is influenced by several diseases. We aimed to evaluate the association between serum ferritin concentration and the complications and nature of diabetes mellitus (DM). We examined association of ferritin concentration, fasting and post-prandial glucose levels and glycated hemoglobin in 329 patients with type 2 diabetes mellitus and 269 healthy controls. In the present study, 41 of 150 poorly controlled diabetic patients and 31 of 119 cases had hyperferritinemia. We confirmed that serum ferritin was increased in diabetic patients as long as glycemic control is not achieved. There was also a correlation between ferritin level and diabetic retinopathy. In conclusion, this study showed an independent positive association between serum ferritin concentration and markers of glucose homeostasis.
血清铁蛋白水平与体内铁储备有关，并受多种疾病影响。我们旨在评估血清铁蛋白浓度与糖尿病（DM）并发症及性质之间的关联。我们检测了329例2型糖尿病患者和269例健康对照者的铁蛋白浓度、空腹及餐后血糖水平和糖化血红蛋白之间的关联。在本研究中，150例血糖控制不佳的糖尿病患者中有41例、119例中有31例存在高铁蛋白血症。我们证实，只要血糖控制未达标，糖尿病患者的血清铁蛋白就会升高。铁蛋白水平与糖尿病视网膜病变之间也存在相关性。总之，本研究显示血清铁蛋白浓度与葡萄糖稳态指标之间存在独立的正相关。
