Institute of Cognitive Science, Carleton University, Ottawa, Ontario.
Can J Psychiatry. 2010 Jan;55(1):50-6. doi: 10.1177/070674371005500108.
To compare employment pay, count of infractions, and clinical symptoms in psychiatric inmates treated with clozapine or other antipsychotics after 6 months of treatment.
Clinical charts and institutional offence records of psychiatric inmates (n = 98), comprised of those on clozapine (n = 65) and on other antipsychotics (n = 33), were reviewed at baseline and after 6 months of treatment. The outcome measures used were Brief Psychiatric Rating Scale (BPRS) scores, employment pay, medication compliance, and the frequency of institutional offences. A binary logistic regression model was used to analyze a categorical change in pay variable, while a negative binomial model was used to analyze the frequency of infractions.
Treatment with clozapine was associated with greater odds of a pay increase (OR = 3.13; 95% CI 1.3 to 7.53, P = 0.01). However, patients on other antipsychotics had a more favourable improvement in BPRS (F = 5.44, df = 1,57, P = 0.02). Patients on other antipsychotics also had a higher count of posttreatment offences (Incidence Rate Ratio = 2.22; 95% CI 1.11 to 4.41, P = 0.02).
Clozapine probably has a favourable effect on inmate behaviour and institutional adjustment. This effect can last up to 36 months after the initial dose.
比较氯氮平与其他抗精神病药物治疗 6 个月后精神病患者的就业薪酬、违规次数和临床症状。
回顾基线和治疗 6 个月后精神科住院患者（氯氮平组 n=65，其他抗精神病药物组 n=33）的临床病历和机构违规记录。使用简明精神病评定量表（BPRS）评分、就业薪酬、药物依从性和机构违规频率作为结局指标。采用二项逻辑回归模型分析薪酬变量的分类变化，采用负二项回归模型分析违规频率。
氯氮平治疗与薪酬增加的几率增加相关（OR=3.13；95%CI 1.3 至 7.53，P=0.01）。然而，其他抗精神病药物治疗的患者 BPRS 改善更有利（F=5.44，df=1,57，P=0.02）。其他抗精神病药物治疗的患者治疗后违规次数也更高（发病率比=2.22；95%CI 1.11 至 4.41，P=0.02）。
氯氮平可能对囚犯的行为和机构适应有有利影响。这种影响可持续到初始剂量后 36 个月。
