Li Cheng-Wan, Jiang Dong-Lin, Qiao Jian, Sun Jun-Ming, Huang Jian-Ping, Chen Hai-Ping, Zhu Hong
Department of Pediatrics, Third Affiliated Hospital of Nantong University, Wuxi, Jiangsu 214041, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2010 Jan;12(1):40-2.
Some research has shown that C-reactive protein (CRP), leptin, soluble leptin receptor (sLR) and blood lipids are involved in the development of obesity. This study aimed to investigate the changes of leptin resistance, blood lipids and inflammatory response before and after the exercise therapy in children with obesity.
Fifty-one obese children at ages of 12 years received an exercise therapy for 2 months. The levels of serum leptin, sLR, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hs-CRP) were measured before and after the exercise therapy. Forty normal children served as the control group.
Compared with the control group, serum levels of leptin, TG, TC, LDL-C and hs-CRP and the body mass index (BMI) in the obese group increased (p<0.01), while the serum level of sLR decreased significantly (p<0.05). The levels of hs-CRP, leptin, TC, TG, LDL-C and BMI in the obese group were significantly reduced after the exercise therapy (p<0.05). In the obese group, the serum leptin level was positively correlated with the levels of blood lipids and hs-CRP (p<0.05); serum levels of leptin and hs-CRP were negatively correlated with the sLR level (p<0.05); the hs-CRP level was positively correlated with the levels of blood lipids (p<0.01).
Leptin resistance and the changes of blood lipids and inflammatory response are found in children with obesity. Exercise therapy can partially improve these changes.
一些研究表明，C反应蛋白（CRP）、瘦素、可溶性瘦素受体（sLR）和血脂与肥胖的发生发展有关。本研究旨在探讨肥胖儿童运动治疗前后瘦素抵抗、血脂和炎症反应的变化。
51名12岁的肥胖儿童接受了为期2个月的运动治疗。在运动治疗前后测量血清瘦素、sLR、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高敏C反应蛋白（hs-CRP）水平。40名正常儿童作为对照组。
与对照组相比，肥胖组血清瘦素、TG、TC、LDL-C和hs-CRP水平及体重指数（BMI）升高（p<0.01），而血清sLR水平显著降低（p<0.05）。运动治疗后，肥胖组hs-CRP、瘦素、TC、TG、LDL-C和BMI水平显著降低（p<0.05）。在肥胖组中，血清瘦素水平与血脂和hs-CRP水平呈正相关（p<0.05）；血清瘦素和hs-CRP水平与sLR水平呈负相关（p<0.05）；hs-CRP水平与血脂水平呈正相关（p<0.01）。
肥胖儿童存在瘦素抵抗以及血脂和炎症反应的变化。运动治疗可部分改善这些变化。
