Yang Nian-hong, Zhou Yun-zhen, Mao Li-mei, Huang Yan, Qi Zhen-ying
Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2003 May;37(3):186-8.
To investigate the relationship between fasting serum levels of leptin, glucose, insulin resistance, lipids in simple obese children.
Fasting serum levels of leptin and insulin (Fins) were measured by RIA in 42 obese and 42 normally-weighted children matched on age, sex and height, and their total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) were analyzed with enzymatic methods. HOMA-IR and LDL-C were calculated.
Serum level of leptin was (2.74 - 45.12) micro g/L and (0.53 - 10.18) micro g/L in obese and normally-weighted children, respectively, with an average level of leptin (log) significantly higher in obese group than that in control group (P < 0.001). Serum level of leptin was positively correlated with BMI, WHR and percentage of body fat. Of obese children, 83% were leptin resistant. Serum levels of TC, TG, LDL-C and insulin were significantly higher in obese leptin-resistant group than those in normally-weighted control group, but no significant difference in them between obese leptin-sensitive group and its normally-weighted control group was observed. Significantly higher serum levels of TG and lower HDL-C were observed in obese leptin-resistant group, as compared with those in obese leptin-sensitive group.
A big difference in serum level of leptin between obese and normally-weighted children was found, suggesting most obese children were resistant to endogenous leptin. Leptin resistance correlated significantly with the risk of metabolic syndrome and cardiovascular disease, indicating serum level of leptin could be used as an indicator in screening obese children at high risk.
探讨单纯性肥胖儿童空腹血清瘦素水平与血糖、胰岛素抵抗及血脂之间的关系。
采用放射免疫分析法（RIA）测定42例肥胖儿童和42例年龄、性别、身高相匹配的正常体重儿童的空腹血清瘦素和胰岛素（Fins）水平，并用酶法分析其总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）水平。计算稳态模型评估的胰岛素抵抗指数（HOMA-IR）和低密度脂蛋白胆固醇（LDL-C）。
肥胖儿童和正常体重儿童的血清瘦素水平分别为（2.74 - 45.12）μg/L和（0.53 - 10.18）μg/L，肥胖组血清瘦素（对数）平均水平显著高于对照组（P < 0.001）。血清瘦素水平与体重指数（BMI）、腰臀比（WHR）和体脂百分比呈正相关。肥胖儿童中，83%存在瘦素抵抗。肥胖瘦素抵抗组的血清TC、TG、LDL-C和胰岛素水平显著高于正常体重对照组，但肥胖瘦素敏感组与其正常体重对照组之间无显著差异。与肥胖瘦素敏感组相比，肥胖瘦素抵抗组的血清TG水平显著升高，HDL-C水平显著降低。
肥胖儿童与正常体重儿童的血清瘦素水平存在较大差异，提示大多数肥胖儿童对内源性瘦素抵抗。瘦素抵抗与代谢综合征和心血管疾病风险显著相关，表明血清瘦素水平可作为筛查肥胖高危儿童的指标。
