School of Public Health, Taipei Medical University Hospital, Taipei, Taiwan.
Am J Obstet Gynecol. 2010 Feb;202(2):164.e1-8. doi: 10.1016/j.ajog.2009.09.029.
The objective of the study was to determine whether maternal peptic ulcer disease (PUD) is associated with increased risk of adverse pregnancy outcomes, using a nationwide population-based dataset.
We identified a total of 2120 women who gave birth from 2001 to 2003 with a diagnosis of PUD during pregnancy. Then 10,600 unaffected pregnant women were matched with cases in age and year of delivery. Multivariate logistic regression analyses were performed for estimation.
We found that PUD was independently associated with a 1.18-fold risk of low birthweight (95% confidence interval [CI], 1.01-1.30), a 1.20-fold risk of preterm delivery (95% CI, 1.02-1.41), and a 1.25-fold (95% CI, 1.11-1.41) higher risk of babies small for gestational age, compared with unaffected mothers, after adjusting for potential confounders. In further examining women with treated PUD, improved effects of PUD medication on the risks of adverse neonate outcomes were not identified.
We document increased risk of adverse birth outcomes for women with PUD during pregnancy.
本研究旨在利用全国性基于人群的数据集，确定孕妇消化性溃疡（PUD）是否与不良妊娠结局风险增加相关。
我们共确定了 2120 名 2001 年至 2003 年期间在怀孕期间被诊断为 PUD 的分娩妇女，并与年龄和分娩年份相匹配的 10600 名未受影响的孕妇进行了配对。采用多变量逻辑回归分析进行估计。
我们发现，与未受影响的母亲相比，PUD 与低出生体重（95%置信区间 [CI]，1.01-1.30）、早产（95%CI，1.02-1.41）和小于胎龄儿（95%CI，1.11-1.41）的风险分别增加了 1.18 倍、1.20 倍和 1.25 倍，调整潜在混杂因素后。进一步研究接受治疗的 PUD 妇女发现，PUD 药物治疗对不良新生儿结局风险的改善效果并不明显。
我们记录了孕妇 PUD 与不良分娩结局风险增加之间的关联。
