比较腹膜癌病评分方法在预测晚期卵巢癌可切除性和预后中的作用。

Comparison of peritoneal carcinomatosis scoring methods in predicting resectability and prognosis in advanced ovarian cancer.

机构信息

Department of Gynecology-Obstetrics and Prediction Unit (INSERM U953, Epidemiological Research Unit on Perinatal and Women's Health), Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, and CancerEst, Université Pierre et Marie Curie, Paris, France.

出版信息

Am J Obstet Gynecol. 2010 Feb;202(2):178.e1-178.e10. doi: 10.1016/j.ajog.2009.10.856.

DOI:10.1016/j.ajog.2009.10.856

PMID:20113693

Abstract

OBJECTIVE

The aim of this study was to compare carcinomatosis scores, and to determine their relevance to predict resectability, morbidity, and outcome.

STUDY DESIGN

From 2005-2008, 61 patients underwent surgery for ovarian cancer. We compared International Federation Gynecology and Obstetrics (FIGO), peritoneal cancer index, Eisenkop, Aletti, Fagotti, and Fagotti-modified scores.

RESULTS

There was a strong correlation between the different scores. In predicting resectability, Fagotti-modified and peritoneal cancer index outperformed other scores. We demonstrated a strong association between the occurrence of postoperative complications and Aletti, peritoneal cancer index, and Eisenkop scores (P < .0001). For progression-free survival, we observed significant differences among FIGO, peritoneal cancer index, Eisenkop, Fagotti-modified, and Aletti stages (P < .05). For stage III/IV patients, only Aletti score remains significant to predict resectability. This suggests that complete respectability is more related to the surgical effort than to the extent of the disease.

CONCLUSION

Alternative ranking systems provide additional information over FIGO for complete resectability, complications, and survival.

摘要

目的

本研究旨在比较癌转移评分，并确定其对预测可切除性、发病率和预后的相关性。

研究设计

2005 年至 2008 年，61 例卵巢癌患者接受了手术治疗。我们比较了国际妇产科联合会（FIGO）、腹膜癌指数、Eisenkop、Aletti、Fagotti 和 Fagotti 改良评分。

结果

不同评分之间存在很强的相关性。在预测可切除性方面，Fagotti 改良评分和腹膜癌指数优于其他评分。我们发现术后并发症的发生与 Aletti、腹膜癌指数和 Eisenkop 评分之间存在很强的关联（P<0.0001）。对于无进展生存期，我们观察到 FIGO、腹膜癌指数、Eisenkop、Fagotti 改良和 Aletti 分期之间存在显著差异（P<0.05）。对于 III/IV 期患者，只有 Aletti 评分仍然可以预测可切除性。这表明完全可切除性与手术难度更相关，而与疾病的严重程度无关。