Sarah Racine IVF Unit and the Department of Gynecology, Lis Maternity Hospital, Tel-Aviv Sourasky Medical Centre affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Reprod Biomed Online. 2010 Feb;20(2):256-60. doi: 10.1016/j.rbmo.2009.11.015. Epub 2009 Dec 3.
The aim was to compare obstetric outcomes of IVF singleton pregnancies diagnosed with vanishing twin (VT) syndrome with those pregnancies originating as singleton pregnancies and with twin pregnancies. In this case control study, 57 patients diagnosed with VT syndrome were matched and compared with 171 singleton controls and 171 twin controls. Mean gestational age was 35.1+/-3.7 versus 38.2+/-2.6 weeks (P=0.001) for patients and singleton controls respectively. Birth weights were 2834.4+/-821.2 versus 3036+/-489.3g (P=0.02), proportion of low birth weight (< 2500 g) was 33.3 versus 11.7% (P=0.0001) and very low birth weight (< 1500 g) 3.5 versus 0.6% for patients and singleton controls respectively. The proportion of deliveries before 28 weeks of gestation was 7.0 versus 1.2% (P=0.01) for patients and singleton controls respectively. When comparing the study group to twin control pregnancies, a similar gestational age at delivery (35 weeks) and rate of preterm birth (23%) were found. In conclusion, pregnancies diagnosed with the VT syndrome after IVF carry a higher rate of adverse obstetric outcomes in terms of preterm deliveries and lower birth weight, compared with IVF pregnancies that were originally singleton. Additionally, significant similarities were observed in the obstetrics outcome of vanishing twin pregnancies and twin pregnancies.
本研究旨在比较体外受精（IVF）后诊断为双胎消失（VT）综合征的单胎妊娠与单纯单胎妊娠和双胎妊娠的产科结局。在这项病例对照研究中，57 例诊断为 VT 综合征的患者与 171 例单纯单胎妊娠患者和 171 例双胎妊娠患者进行了匹配和比较。患者与单纯单胎妊娠患者的平均孕龄分别为 35.1+/-3.7 周和 38.2+/-2.6 周（P=0.001）。出生体重分别为 2834.4+/-821.2g 和 3036+/-489.3g（P=0.02），低出生体重（<2500g）的比例分别为 33.3%和 11.7%（P=0.0001），极低出生体重（<1500g）的比例分别为 3.5%和 0.6%。患者与单纯单胎妊娠患者的早产分娩率（<28 周）分别为 7.0%和 1.2%（P=0.01）。与双胎妊娠对照组相比，研究组的分娩孕周相似（35 周），早产率也相似（23%）。总之，与最初为单胎的 IVF 妊娠相比，IVF 后诊断为 VT 综合征的妊娠在早产和低出生体重方面的不良产科结局发生率更高。此外，双胎消失妊娠和双胎妊娠的产科结局也存在显著相似性。
