布呋洛尔，苯并呋喃 - 2 - 乙醇胺系列中的一种新型β - 肾上腺素能受体阻滞剂。第2部分：药理学。
Bufuralol, a new beta-adrenoceptor blocking agent in a series of benzofuran-2-ethanolamines. Part 2: pharmacology.
作者信息
Hamilton T C, Parkes M W
出版信息
Arzneimittelforschung. 1977 Jul;27(7):1410-7.
PMID:20114
Abstract
1-(7-Ethylbenzofuran-2-yl)-2-tert.-butylamino-1-hydroxyethane hydrochloride (bufuralol) is a non-selective beta-adrenoceptor blocking agent which closely resembles propranolol in its properties, including potency. Bufuralol is devoid of alpha-adrenoceptor blocking activity but possesses beta-adrenoceptor agonist activity. beta-Adrenoceptor blocking activity resides mainly in the (-)-isomer though membrane stabilising properties are associated with both optical isomers.
摘要
1-（7-乙基苯并呋喃-2-基）-2-叔丁氨基-1-羟基乙烷盐酸盐（布呋洛尔）是一种非选择性β-肾上腺素受体阻滞剂，其性质（包括效能）与普萘洛尔非常相似。布呋洛尔没有α-肾上腺素受体阻断活性，但具有β-肾上腺素受体激动活性。β-肾上腺素受体阻断活性主要存在于（-）-异构体中，而膜稳定特性与两种光学异构体都有关。
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