布呋洛尔，一种新型β-肾上腺素能受体阻滞剂。第1部分：一系列苯并呋喃-2-乙醇胺的合成与构效关系研究。
Bufuralol, a new beta-adrenoceptor blocking agent. Part 1: synthesis and structure-activity studies in a series of benzofuran-2-ethanolamines.
作者信息
Fothergill G A, Osbond J M, Wickens J C
出版信息
Arzneimittelforschung. 1977;27(5):978-81. doi: 10.1002/chin.197737180.
PMID:18158
Abstract
The synthesis and resolution of a new beta-adrenoceptor blocking agent, 1-(7-ethylbenzofuran-2-yl)-2-tert.-butylamino-1-hydroxyethane (bufuralol) are described. Structure-activity studies leading to selection of the title compound are discussed.
摘要
本文描述了一种新型β-肾上腺素受体阻滞剂1-(7-乙基苯并呋喃-2-基)-2-叔丁氨基-1-羟基乙烷（布呋洛尔）的合成与拆分。讨论了导致选择该标题化合物的构效关系研究。
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