Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School of Medicine, 2021 6(th) Street S.E., Minneapolis, MN 55455, USA.
Neuroimage. 2010 May 1;50(4):1456-63. doi: 10.1016/j.neuroimage.2010.01.053. Epub 2010 Jan 28.
In this work, we exploited the superior capability of high-resolution functional magnetic resonance imaging (fMRI) for functional mapping of ocular dominance layer (ODL) in the cat lateral geniculate nucleus (LGN). The stimulus-evoked neuronal activities in the LGN ODLs associated with contralateral- and ipsilateral-eye visual inputs were successfully differentiated and mapped using both blood-oxygenation-level dependent (BOLD)-weighted and cerebral blood volume (CBV)-weighted fMRI methods. The morphology of mapped LGN ODLs was in remarkable consistency with histology findings in terms of ODL shape, orientation, thickness and eye-dominance. Compared with the BOLD signal, the CBV signal provides higher reproducibility and better spatial resolvability for function mapping of LGN because of improved contrast-to-noise ratio and point-spread function. The capability of fMRI for non-invasively imaging the functional sub-units of ODL in a small LGN overcomes the limitation of conventional neural-recording approach, and it opens a new opportunity for studying critical roles of LGN in brain function and dysfunction at the fine scale of ocular dominance layer.
在这项工作中，我们利用高分辨率功能磁共振成像 (fMRI) 的卓越能力，对猫外侧膝状体核 (LGN) 的眼优势层 (ODL) 进行功能映射。使用血氧水平依赖 (BOLD) 加权和脑血容量 (CBV) 加权 fMRI 方法，成功区分和映射了与对侧和同侧眼视觉输入相关的 LGN ODL 中的刺激诱发神经元活动。映射的 LGN ODL 的形态在 ODL 形状、方向、厚度和眼优势方面与组织学发现具有显著的一致性。与 BOLD 信号相比，CBV 信号为 LGN 的功能映射提供了更高的可重复性和更好的空间分辨率，因为它提高了对比度噪声比和点扩散函数。fMRI 无创成像小 LGN 中 ODL 功能亚单位的能力克服了传统神经记录方法的局限性，为研究 LGN 在精细的眼优势层水平上的大脑功能和功能障碍中的关键作用开辟了新的机会。
