Hajak G, Huether G, Blanke J, Blömer M, Freyer C, Poeggeler B, Reimer A, Rodenbeck A, Schulz-Varszegi M, Rüther E
Department of Psychiatry, University of Göttingen, Germany.
Pharmacopsychiatry. 1991 Jan;24(1):17-20. doi: 10.1055/s-2007-1014427.
The sleep-inducing mechanisms of L-Tryptophan (L-Trp) are generally thought to be mediated by a central serotonergic activation. Evidence is presented that some effects of L-Trp on sleep may be mediated by melatonin, a Trp-metabolite with sedative properties. Trp effects on vigilance, sleep, and plasma-melatonin concentrations were measured after double-blind application of 0, 1, 3, and 5 g L-Trp in nine and five healthy probands during daytime and nighttime, respectively. A significant sleep-inducing effect was observed after L-Trp administration during daytime and nighttime. The infusions of L-Trp caused a massive elevation of plasma melatonin levels. This effect was significant both during the night and the day, indicating that the increment of circulating melatonin may be of extrapineal origin.
一般认为，L-色氨酸（L-Trp）的助眠机制是由中枢5-羟色胺能激活介导的。有证据表明，L-Trp对睡眠的某些影响可能是由褪黑素介导的，褪黑素是一种具有镇静特性的色氨酸代谢产物。分别在白天和夜间对9名和5名健康受试者双盲施用0、1、3和5 g L-Trp后，测量色氨酸对警觉性、睡眠和血浆褪黑素浓度的影响。在白天和夜间施用L-Trp后均观察到显著的助眠效果。输注L-Trp导致血浆褪黑素水平大幅升高。这种效应在白天和夜间均显著，表明循环褪黑素的增加可能源于松果体外。
