Department of Neurosurgery, School of Medicine, Zonguldak Karaelmas University, Kozlu, Zonguldak 67600, Turkey.
J Clin Neurosci. 2010 Apr;17(4):490-4. doi: 10.1016/j.jocn.2009.05.041. Epub 2010 Jan 29.
The present study aimed to investigate the neuroprotective efficacy of dexmedetomidine in a rat experimental spinal cord injury model. The rats (n=40) were equally divided into four groups: G1, G2, G3, and G4. Rats in the G1 group underwent a laminectomy only. For the rats in the G2, G3, and G4 groups, spinal cord injury was induced by placing an aneurysm clip extradurally for 60 s at T10. The rats in G2 did not receive any post-injury treatment. Immediately after trauma was induced, rats in G3 were given methylprednisolone (30 mg/kg) and in G4, dexmedetomidine (10 microg/kg), both intraperitoneally. The rats were sacrificed under anesthesia 24 hours later and 1.5 cm lengths of injured spinal cord were obtained. Malonyldialdehyde values were significantly increased in G2 compared to G1, G3 and G4 (p<0.05). The neuronal cell count in G1 was significantly higher than in G2 and G3 (p=0.0001; p=0.007). G4 had higher cell counts compared to G2 and G3 (p=0.0001; p=0.05). These findings indicated that dexmedetomidine might have neuroprotective effects in spinal cord injury.
本研究旨在探讨右美托咪定在大鼠实验性脊髓损伤模型中的神经保护作用。将 40 只大鼠等分为 4 组：G1 组、G2 组、G3 组和 G4 组。G1 组仅行椎板切除术。G2、G3 和 G4 组大鼠通过硬膜外放置动脉瘤夹 60s 造成脊髓损伤。G2 组大鼠未接受任何损伤后治疗。损伤后立即，G3 组大鼠给予甲泼尼龙（30mg/kg），G4 组大鼠给予右美托咪定（10μg/kg），均腹腔内给药。24 小时后，大鼠在麻醉下处死，取 1.5cm 长的损伤脊髓。与 G1、G3 和 G4 组相比，G2 组丙二醛值显著升高（p<0.05）。G1 组神经元细胞计数明显高于 G2 组和 G3 组（p=0.0001；p=0.007）。与 G2 组和 G3 组相比，G4 组细胞计数更高（p=0.0001；p=0.05）。这些发现表明，右美托咪定可能对脊髓损伤具有神经保护作用。
