Department of Neurosurgery, Zonguldak Bülent Ecevit University Faculty of Medicine, Zonguldak-Turkey.
Department of Radiation Oncology, Zonguldak Bulent Ecevit University Faculty of Medicine, Zonguldak-Turkey.
Ulus Travma Acil Cerrahi Derg. 2022 Mar;28(3):233-241. doi: 10.14744/tjtes.2021.70728.
Annona muricata (AM) (graviola) is a plant that grows in tropical regions and is thought to be good for many diseases by local people. Unfortunately, there is no acceptable medical treatment for spinal cord injury (SCI) yet. In our study, we investigated the neuropeotective effects of AM leaf extract on SCI in an experimental rat model.
A total of 40 Wistar albino rats were randomly divided into five equal groups (n=8). Group 1 was the control group in which only laminectomy was performed. Trauma was induced in four groups after laminectomy. Group 2 (untreated trauma group) was given no medication. In Group 3, a single intraperitoneal dose of methylprednisolone (30 mg/kg) was administered after trauma. The rats in Groups 4 received a low dose (100 mg/kg) of AM leaf extracts by oral gavage one week before trauma while the rats in Group 5 received a high-dose (300 mg/kg) of these extracts by oral gavage one week before trauma. All rats, including the control group, were sacrificed 24 h after the trauma was created.
Tissue samples taken to evaluate the neuroprotective effect were examined biochemically and histopathologically. Inflam-matory findings in the trauma group were significantly better in both groups treated with AM. There was no difference between the groups in terms of clinical motor examination and inclined plane test results.
Our histopathological and biochemical results showed that AM is an agent with neuroprotective effects in trau-matic SCI.
Annona muricata（AM）（百香果）是一种生长在热带地区的植物，当地人认为它对许多疾病都有好处。不幸的是，目前还没有可接受的治疗脊髓损伤（SCI）的方法。在我们的研究中，我们在实验性大鼠模型中研究了 AM 叶提取物对 SCI 的神经保护作用。
总共 40 只 Wistar 白化大鼠被随机分为五组（每组 8 只）。第 1 组为对照组，仅进行椎板切除术。在椎板切除术后，4 组动物均造成创伤。第 2 组（未治疗的创伤组）未给予任何药物。第 3 组在创伤后单次腹腔内给予甲泼尼龙（30mg/kg）。第 4 组大鼠在创伤前一周通过口服给予低剂量（100mg/kg）AM 叶提取物，第 5 组大鼠在创伤前一周通过口服给予高剂量（300mg/kg）这些提取物。包括对照组在内的所有大鼠均在创伤后 24 小时处死。
为评估神经保护作用而采集的组织样本进行了生化和组织病理学检查。在 AM 治疗的两组中，创伤组的炎症发现明显改善。两组在临床运动检查和斜面试验结果方面没有差异。
我们的组织病理学和生化结果表明，AM 是外伤性 SCI 具有神经保护作用的药物。
