缓激肽通过环磷酸腺苷系统在大鼠十二指肠中的作用。
Bradykinin action in the rat duodenum through the cyclic AMP system.
作者信息
Paegelow I, Reissmann S, Vietinghoff G, Römer W, Arold H
出版信息
Agents Actions. 1977 Oct;7(4):447-51. doi: 10.1007/BF01966851.
PMID:201163
Abstract
Activators of the adenylate cyclase or inhibitors of the cAMP-phosphodiesterase, respectively, potentiate the bradykinin-induced relaxation of the rat duodenum, whereas imidazole as a stimulator of the cAMP-phosphodiesterase reduces the relaxation. The experiments indicate a linkage between the adenylate cyclase system with the biological action of bradykinin on the rat duodenum. In contrast, no similar effect has been observed on the rat uterus.
摘要
腺苷酸环化酶激活剂或环磷酸腺苷磷酸二酯酶抑制剂分别增强缓激肽诱导的大鼠十二指肠舒张，而作为环磷酸腺苷磷酸二酯酶刺激剂的咪唑则减弱这种舒张。实验表明腺苷酸环化酶系统与缓激肽对大鼠十二指肠的生物学作用之间存在联系。相比之下，在大鼠子宫上未观察到类似效应。
Zotero 插件