[Inspiratory support versus spontaneous breathing during preoxygenation in healthy subjects. A randomized, double blind, cross-over trial].

OBJECTIVE

Applying an inspiratory support (AI) and a positive end expiratory pressure (PEP) could increase the effectiveness of the preoxygenation.

STUDY DESIGN

This randomized double blinded controlled study compares the impact on the expiratory oxygen fraction (FEO(2)) of two levels of AI with PEP to a traditional preoxygenation.

PATIENTS AND METHODS

Twenty healthy volunteers were studied. The criteria of exclusion were a body mass index >30, the presence of beard or moustache and the claustrophobia. Each subject went through three modes of preoxygenation during 3 minutes each in a random order: 1-spontaneous ventilation (VS), 2-preoxygenation with AI with 4 cmH(2)O/PEP 4 cmH(2)O (AI-4/PEP-4), 3-preoxygenation with AI with 6 cmH(2)O/PEP 4 cmH(2)O (AI-6/PEP-4). Subject's tolerance and leaks were also noted.

RESULTS

The FEO(2) at the end of the 3 minutes of preoxygenation was higher (p<0,001) with AI-4/PEP-4 (94+/-3%) and AI-6/PEP-4 (94+/-4%) than with technique VS (89+/-6%). One hundred percent and 90% of the participants reached one FEO(2)=90% with AI-4/PEP-4 and AI-6/PEP-4 respectively vs 65% with VS (p=0.0013). The participants tolerated better the VS and the AI-4/PEP-4 than the AI-6/PEP-4. More leaks were noted with the AI-6/PEP-4 than with the VS and the AI-4/PEP-4.

CONCLUSION

This study shows applying AI plus PEP during preoxygenation improves its effectiveness in the healthy subjects. It also suggests that, in a population of healthy volunteers, combination AI-4/PEP-4 is preferable to AI-6/PEP-4 because so effective, but better tolerated.