National Heart and Lung Institute, Imperial College, London, UK.
Cardiovasc Pathol. 2011 Mar-Apr;20(2):107-9. doi: 10.1016/j.carpath.2010.01.005. Epub 2010 Feb 8.
Primary malignant pericardial mesothelioma is an extremely rare tumor. One of the largest autopsy series gave an incidence of primary pericardial tumors of 0.0022%, of which mesothelioma is the most common type. A male predominance of the disease has been described, and the majority of cases occur in the fourth to seventh decades of life. Unlike peritoneal and pleural mesothelioma, there has been no definite correlation between asbestos exposure and pericardial disease. Malignant pericardial mesothelioma carries a poor prognosis with few successful treatment strategies and little benefit from radiation and chemotherapy. We report a case of a 66-year-old man who presented with shortness of breath, right shoulder pain, and peripheral edema of the lower limbs. A large pericardial effusion was seen on echocardiography, which was drained but the patient died the following day. A malignant tumor was found on autopsy and a final diagnosis of primary malignant pericardial mesothelioma was made following histopathological examination.
原发性恶性心包间皮瘤是一种极为罕见的肿瘤。最大的尸检系列之一显示原发性心包肿瘤的发病率为 0.0022%，其中间皮瘤是最常见的类型。该病以前多发生于男性，大多数病例发生在 40 岁至 70 岁。与腹膜和胸膜间皮瘤不同，石棉暴露与心包疾病之间没有明确的相关性。恶性心包间皮瘤预后不良，治疗策略收效甚微，放疗和化疗也收效甚微。我们报告了一例 66 岁男性患者，因呼吸困难、右肩部疼痛和下肢周围性水肿就诊。超声心动图显示大量心包积液，行引流治疗，但患者次日死亡。尸检发现恶性肿瘤，经组织病理学检查后最终诊断为原发性恶性心包间皮瘤。
