维生素 D2 治疗小儿囊性纤维化患者的短暂疗效。
Transient effectiveness of vitamin D2 therapy in pediatric cystic fibrosis patients.
机构信息
Eudowood Division of Pediatric Respiratory Sciences, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
出版信息
J Cyst Fibros. 2010 Mar;9(2):143-9. doi: 10.1016/j.jcf.2010.01.002. Epub 2010 Feb 8.
BACKGROUND
The effectiveness of current treatment recommendations for vitamin D insufficiency in children with CF is unknown. Therefore, we assessed the effectiveness of vitamin D(2) 50,000 IU once daily for 28 days for vitamin D insufficiency.
METHODS
Retrospective chart review of pediatric CF patients from 2006-2008. Vitamin D(2) 50,000 IU daily for 28 days was given to patients with 25-OHD <30 ng/mL and repeat 25-OHD levels were obtained after completion of therapy.
RESULTS
One hundred forty-seven levels from 97 individuals were assessed. Success of treatment was 54% (n=80/147). Seventeen of 39 patients (43%) followed for an additional 6-18 months were able to maintain levels of >or=30 ng/mL.
CONCLUSIONS
Vitamin D(2) 50,000 IU daily for 28 days was effective in correcting vitamin D insufficiency in approximately 50% of subjects. However, almost half of successfully treated patients were unable to maintain normal 25-OHD levels >6 months after completion of therapy, implying that this effect is transient.
背景
目前针对 CF 患儿维生素 D 不足的治疗推荐的有效性尚不清楚。因此，我们评估了每日口服维生素 D(2)50000IU28 天治疗维生素 D 不足的效果。
方法
对 2006-2008 年期间的儿科 CF 患者进行回顾性图表审查。对 25-OHD<30ng/mL 的患者给予每日维生素 D(2)50000IU28 天治疗，治疗完成后获得重复的 25-OHD 水平。
结果
从 97 名患者中评估了 147 个水平。治疗成功率为 54%（80/147）。在随后的 6-18 个月中，39 名患者中的 17 名（43%）能够维持>or=30ng/mL 的水平。
结论
每日口服维生素 D(2)50000IU28 天对大约 50%的患者有效纠正维生素 D 不足。然而，近一半成功治疗的患者在治疗完成后 6 个月内无法维持正常的 25-OHD 水平>6 个月，这意味着这种效果是暂时的。
Zotero 插件