Eudowood Division of Pediatric Respiratory Sciences, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
J Cyst Fibros. 2010 Mar;9(2):143-9. doi: 10.1016/j.jcf.2010.01.002. Epub 2010 Feb 8.
The effectiveness of current treatment recommendations for vitamin D insufficiency in children with CF is unknown. Therefore, we assessed the effectiveness of vitamin D(2) 50,000 IU once daily for 28 days for vitamin D insufficiency.
Retrospective chart review of pediatric CF patients from 2006-2008. Vitamin D(2) 50,000 IU daily for 28 days was given to patients with 25-OHD <30 ng/mL and repeat 25-OHD levels were obtained after completion of therapy.
One hundred forty-seven levels from 97 individuals were assessed. Success of treatment was 54% (n=80/147). Seventeen of 39 patients (43%) followed for an additional 6-18 months were able to maintain levels of >or=30 ng/mL.
Vitamin D(2) 50,000 IU daily for 28 days was effective in correcting vitamin D insufficiency in approximately 50% of subjects. However, almost half of successfully treated patients were unable to maintain normal 25-OHD levels >6 months after completion of therapy, implying that this effect is transient.
目前针对 CF 患儿维生素 D 不足的治疗推荐的有效性尚不清楚。因此，我们评估了每日口服维生素 D(2)50000IU28 天治疗维生素 D 不足的效果。
对 2006-2008 年期间的儿科 CF 患者进行回顾性图表审查。对 25-OHD<30ng/mL 的患者给予每日维生素 D(2)50000IU28 天治疗，治疗完成后获得重复的 25-OHD 水平。
从 97 名患者中评估了 147 个水平。治疗成功率为 54%（80/147）。在随后的 6-18 个月中，39 名患者中的 17 名（43%）能够维持>or=30ng/mL 的水平。
每日口服维生素 D(2)50000IU28 天对大约 50%的患者有效纠正维生素 D 不足。然而，近一半成功治疗的患者在治疗完成后 6 个月内无法维持正常的 25-OHD 水平>6 个月，这意味着这种效果是暂时的。
