Kumaratne Mohan, Vigneron Franck, Cisneros Jasmine
Fountain Valley Regional Hospital, Fountain Valley, CA, USA.
California State University Northridge, Northridge, CA, USA.
Glob Pediatr Health. 2020 Dec 16;7:2333794X20976240. doi: 10.1177/2333794X20976240. eCollection 2020.
Multiple epidemiological studies have shown that vitamin D deficiency is highly prevalent amongst adolescents in the USA. However, recommendations regarding the treatment of vitamin D deficiency in healthy adolescents are not well defined. We carried out a prospective pilot study, to determine whether treatment with 2000 international units of vitamin D3 daily for 3 months, would normalize the vitamin D levels in vitamin D deficient adolescents. Following treatment there was a 56.02% increase in the vitamin D levels from the mean baseline values and 80.39% of the subjects normalized their vitamin D levels. There were no adverse effects associated with this intervention. This study offers complementary guidelines to the existing recommendations from the American Academy of Pediatrics on the optimal dose and duration of vitamin D3 therapy in vitamin D deficient, but otherwise healthy adolescents. Further prospective, large scale, case control studies are indicated to validate our results.
多项流行病学研究表明，维生素D缺乏在美国青少年中非常普遍。然而，关于健康青少年维生素D缺乏症治疗的建议并不明确。我们进行了一项前瞻性试点研究，以确定每天服用2000国际单位维生素D3，持续3个月的治疗方法是否能使维生素D缺乏的青少年的维生素D水平恢复正常。治疗后，维生素D水平较平均基线值提高了56.02%，80.39%的受试者维生素D水平恢复正常。该干预措施未产生不良反应。本研究为美国儿科学会关于维生素D缺乏但其他方面健康的青少年维生素D3治疗的最佳剂量和持续时间的现有建议提供了补充指南。需要进一步进行前瞻性、大规模的病例对照研究来验证我们的结果。
