Bertolaso Chiara, Groleau Veronique, Schall Joan I, Maqbool Asim, Mascarenhas Maria, Latham Norma E, Dougherty Kelly A, Stallings Virginia A
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
J Pediatr Gastroenterol Nutr. 2014 Apr;58(4):443-8. doi: 10.1097/MPG.0000000000000272.
The aim of the study was to assess the impact of LYM-X-SORB (LXS), an organized lipid matrix that has been shown to be absorbable without pancreatic enzyme therapy on fat-soluble vitamin status in children with cystic fibrosis (CF) and pancreatic insufficiency (PI).
Children with CF and PI were randomized to daily LXS or an isocaloric placebo comparison supplement for 12 months. Serum vitamins A (retinol), D (25-hydroxyvitamin D[25D]), E (α-tocopherol, α-tocopherol:cholesterol ratio), and K (percentage of undercarboxylated osteocalcin [%ucOC] and plasma proteins induced by vitamin K absence factor II [PIVKA II]) were assessed at baseline and 12 months. Dietary intake was determined using 3-day weighed food records and supplemental vitamin intake by a comprehensive questionnaire.
A total of 58 subjects (32 boys, age 10.3 ± 2.9 years [mean ± standard deviation]) with complete serum vitamin, dietary and supplemental vitamin data were analyzed. After adjusting for dietary and supplemental vitamin intake, serum retinol increased 3.0 ± 1.4 μg/dL (coefficient ± standard error) (adjusted R2 = 0.02, P = 0.03) and vitamin K status improved as demonstrated by a decreased percentage of undercarboxylated osteocalcin of -6.0% ± 1.6% by 12 months (adjusted R2 = 0.15, P < 0.001). These changes occurred in both the LXS and placebo comparison groups. No changes in serum 25D or α-tocopherol were detected. Both nutrition interventions increased caloric intake a mean of 83 ± 666 kcal/day by 12 months.
Vitamins A and K status improved, whereas vitamins D and E status was unchanged during 12 months of LXS and isocaloric placebo comparison supplement in children with CF and PI.
本研究旨在评估LYM-X-SORB（LXS），一种经证实无需胰酶治疗即可吸收的有序脂质基质，对患有囊性纤维化（CF）和胰腺功能不全（PI）的儿童脂溶性维生素状态的影响。
患有CF和PI的儿童被随机分为每日服用LXS或等热量安慰剂对照补充剂，为期12个月。在基线和12个月时评估血清维生素A（视黄醇）、D（25-羟基维生素D[25D]）、E（α-生育酚、α-生育酚：胆固醇比值）和K（未羧化骨钙素的百分比[%ucOC]和维生素K缺乏因子II诱导的血浆蛋白[PIVKA II]）。使用3天称重食物记录确定饮食摄入量，并通过综合问卷确定补充维生素摄入量。
共分析了58名受试者（32名男孩，年龄10.3±2.9岁[平均值±标准差]），他们具有完整的血清维生素、饮食和补充维生素数据。在调整饮食和补充维生素摄入量后，血清视黄醇增加了3.0±1.4μg/dL（系数±标准误差）（调整后的R2=0.02，P=0.03），并且维生素K状态得到改善，表现为到12个月时未羧化骨钙素的百分比降低了-6.0%±1.6%（调整后的R2=0.15，P<0.001）。这些变化在LXS组和安慰剂对照组中均有发生。未检测到血清25D或α-生育酚的变化。两种营养干预措施均使热量摄入量在12个月内平均增加了83±666千卡/天。
在患有CF和PI的儿童中，在12个月的LXS和等热量安慰剂对照补充期间，维生素A和K的状态得到改善，而维生素D和E的状态未发生变化。
