Oxholm P, Winther K, Taaning E
Division of Oral Pathology, School of Dentistry, University of California, San Francisco.
Scand J Rheumatol. 1991;20(1):16-22. doi: 10.3109/03009749109165917.
Ten patients with primary Sjögren's syndrome (7 females) were examined in order to evaluate whether in vivo-bound platelet-associated immunoglobulins (PAIg) and/or in vitro binding of circulating Ig to normal platelets influences platelet function. With an ELISA technique it was found that 9/10 patients had increased amounts of in vivo PAIgG, 4/10 patients of in vivo PAIgA and 5/10 patients of in vivo PAIgM. There was no correlation between patients platelet aggregability and the presence of in vivo PAIg. Incubation of platelets from a healthy person with plasma from the 10 patients caused in vitro binding of IgG in 7/10 cases, of IgA in 0/10 cases and of IgM in 1/10 cases. Adenosine diphosphate (ADP)-induced aggregability of the normal platelets was impaired in 7/10 incubation experiments (no correlation to in vitro PAIg) and unchanged in 3/10 cases. Epinephrine- and collagen-induced platelet aggregability was unchanged in all cases. It is concluded that increased amounts of in vivo and in vitro PAIg seem to occur frequently in patients with primary Sjögren's syndrome, but do not influence platelet aggregability.
为了评估体内结合的血小板相关免疫球蛋白（PAIg）和/或循环免疫球蛋白与正常血小板的体外结合是否会影响血小板功能，对10例原发性干燥综合征患者（7例女性）进行了检查。采用酶联免疫吸附测定（ELISA）技术发现，10例患者中有9例体内PAIgG含量增加，4例体内PAIgA含量增加，5例体内PAIgM含量增加。患者血小板聚集性与体内PAIg的存在之间无相关性。用10例患者的血浆孵育健康人的血小板，7/10的病例出现IgG体外结合，0/10的病例出现IgA体外结合，1/10的病例出现IgM体外结合。在7/10的孵育实验中，正常血小板由二磷酸腺苷（ADP）诱导的聚集性受损（与体外PAIg无相关性），3/10的病例中无变化。在所有病例中，肾上腺素和胶原诱导的血小板聚集性均无变化。得出的结论是，原发性干燥综合征患者体内和体外PAIg含量增加似乎很常见，但不影响血小板聚集性。
