Panzer S, Niessner H, Lechner K, Dudczak R, Jäger U, Mayr W R
Scand J Haematol. 1986 Aug;37(2):97-102. doi: 10.1111/j.1600-0609.1986.tb01780.x.
Levels of platelet-associated immunoglobulins (PAIg) IgG, IgM, IgA and complement C3c were related to parameters of 111Indium-labelled platelet kinetics in 17 patients with chronic idiopathic autoimmune thrombocytopenia (cAITP). Elevated levels of PAIg/C3c were found in 14 patients (82%) (PAIgG n = 13, PAIgM n = 11, PAIgA n = 1, PAC3c n = 5). Only PAIgG correlated with platelet counts (RS = -0.71, p less than 0.01). Mean platelet life span (MLS) was shortened in all patients (median 12.0 h, range 0.3-45.6 h) and correlated with the platelet counts (RS = 0.49, p less than 0.05). MLS was correlated with PAIgG (RS = -0.52, p less than 0.05), but not with PAIgM, PAIgA, or PAC3c. The site of sequestration was splenic in 10 patients and splenic-hepatic in 7 patients. Although no significant correlation between either site of platelet sequestration and any of the investigated PAIg/C3c was demonstrable, platelets coated with higher PAIgG levels were more readily sequestrated in the spleen, while elevations of PAC3c were found in 4 out of 7 patients with hepatic involvement.
在17例慢性特发性自身免疫性血小板减少症（cAITP）患者中，血小板相关免疫球蛋白（PAIg）IgG、IgM、IgA和补体C3c水平与111铟标记的血小板动力学参数相关。14例患者（82%）检测到PAIg/C3c水平升高（PAIgG 13例，PAIgM 11例，PAIgA 1例，PAC3c 5例）。仅PAIgG与血小板计数相关（RS = -0.71，p < 0.01）。所有患者的平均血小板寿命（MLS）均缩短（中位数12.0小时，范围0.3 - 45.6小时），且与血小板计数相关（RS = 0.49，p < 0.05）。MLS与PAIgG相关（RS = -0.52，p < 0.05），但与PAIgM、PAIgA或PAC3c无关。10例患者的血小板扣押部位在脾脏，7例患者为脾 - 肝。尽管血小板扣押部位与任何所研究的PAIg/C3c之间均未显示出显著相关性，但PAIgG水平较高的血小板更容易在脾脏中被扣押，而7例有肝脏受累的患者中有4例检测到PAC3c升高。
