FG 7142 对大鼠味觉特异性饱感的影响。

The effects of FG 7142 on sensory-specific satiety in rats.

机构信息

School of Psychology, University of New South Wales, Sydney 2052, Australia.

出版信息

Behav Brain Res. 2010 May 1;209(1):131-6. doi: 10.1016/j.bbr.2010.01.034. Epub 2010 Jan 29.

DOI:10.1016/j.bbr.2010.01.034

PMID:20117147

Abstract

Three experiments used intake, clusters, and licks per cluster to study the effects of the GABA inverse agonist, FG 7142, on sensory-specific satiety in rats. In Experiment 1, rats were offered one of two palatable solutions and 30min later tested with the same or the other solution. Rats that received the same solution consumed less, exhibited fewer clusters, fewer licks per cluster and a more rapid decline in rate of licking than rats tested with the other solution. In Experiments 2 and 3, rats tested with the same solution under FG 7142 showed fewer clusters and fewer licks per cluster than vehicle rats. Rats tested with the other solution under FG 7142 showed fewer licks per cluster but more clusters than vehicle rats. The results were discussed in terms of the distinction between "liking" and "wanting" and the role of GABA in the former but not the latter.

摘要

三项实验采用摄入量、集群和每个集群的舔舐次数来研究 GABA 反向激动剂 FG 7142 对大鼠感官特异性饱食的影响。在实验 1 中，大鼠提供两种美味溶液中的一种，30 分钟后用相同或另一种溶液进行测试。与用另一种溶液测试的大鼠相比，接受相同溶液的大鼠消耗的量更少，集群次数更少，每个集群的舔舐次数更少，舔舐速度下降更快。在实验 2 和实验 3 中，用 FG 7142 测试相同溶液的大鼠比载体大鼠的集群次数和每个集群的舔舐次数更少。用 FG 7142 测试另一种溶液的大鼠比载体大鼠的每个集群的舔舐次数少，但集群次数多。结果从“喜欢”和“想要”的区别以及 GABA 在前者但不是后者中的作用进行了讨论。