Department of Neurology and Psychiatry, First Affiliated Hospital, Dalian Medical University, Liaoning Province, China.
Neurosci Lett. 2010 Mar 12;472(1):33-7. doi: 10.1016/j.neulet.2010.01.050. Epub 2010 Feb 1.
We compared the pre-attentive processing of emotional faces in major depressive disorder (MDD) patients and matched healthy controls as indexed by the visual mismatch negativity (vMMN) elicited by emotional faces presented in upright and inverted orientations. Compared with standard neutral faces, infrequent emotional faces elicited posterior negativities between 100ms and 350ms. Early vMMN was smaller, while late vMMN was absent in the MDD group, as compared with the normal group. Face inversion decreased the vMMN in the normal group but had no effect on MDD patients. These data suggest the functional dysfunction of pre-attentive expressional information processing in MDD patients, coupled with the disorder of high-level perceptual strategy of processing emotional faces.
我们比较了抑郁症（MDD）患者和匹配的健康对照组在前注意加工情绪面孔时的差异，这种差异通过呈现正立和倒立情绪面孔诱发的视觉失匹配负波（vMMN）来评估。与标准中性面孔相比，不常见的情绪面孔会在 100ms 到 350ms 之间诱发后负性。与正常组相比，MDD 组的早期 vMMN 较小，而晚期 vMMN 缺失。面孔反转会减小正常组的 vMMN，但对面孔反转处理情绪面孔的高级知觉策略紊乱的 MDD 患者没有影响。
