波兰人群散发性帕金森病中 LINGO1(rs9652490) 多态性分析及荟萃分析。
Analysis of LINGO1 (rs9652490) polymorphism in sporadic Parkinson's disease in a Polish population, and a meta-analysis.
机构信息
Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
出版信息
Neurosci Lett. 2010 Mar 12;472(1):53-5. doi: 10.1016/j.neulet.2010.01.055. Epub 2010 Feb 1.
Recently, a variant in LINGO1 (also denominated as LRRN6A) rs9652490:A>G gene has been found to associate with increased risk of essential tremor (ET). Because ET and Parkinson's disease (PD) may be ethiologically related, we proceeded to conduct an analysis of the SNP in PD population. In the current study LINGO1 rs9652490:A>G polymorphism was evaluated in a cohort of 162 Polish patients diagnosed with PD and 177 controls by means of MALDI-TOF mass spectrometry. Any significant differences in rs9652490 genotype or allele frequencies between the studied groups were noted. Our findings demonstrate that LINGO1 SNP (rs9652490) is not associated with sporadic PD in our Polish cohort. A meta-analysis of the available data suggests protective role of rs9652490GG genotype (OR 0.70, 95% CI: 0.51-0.96, p=0.028).
最近，一种 LINGO1（也称为 LRRN6A）基因 rs9652490:A>G 变体被发现与特发性震颤（ET）的风险增加有关。由于 ET 和帕金森病（PD）可能在病因上有关，我们继续对 PD 人群中的 SNP 进行分析。在目前的研究中，通过 MALDI-TOF 质谱法，在 162 名波兰 PD 患者和 177 名对照者的队列中评估了 LINGO1 rs9652490:A>G 多态性。在研究组之间未注意到 rs9652490 基因型或等位基因频率的任何显着差异。我们的研究结果表明，在我们的波兰队列中，LINGO1 SNP（rs9652490）与散发性 PD 无关。对现有数据的荟萃分析表明 rs9652490GG 基因型具有保护作用（OR 0.70，95%CI：0.51-0.96，p=0.028）。
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