LINGO1 多态性在帕金森病中的作用。
Role of LINGO1 polymorphisms in Parkinson's disease.
机构信息
Department of Neurology, Medical University of Vienna, Vienna, Austria.
出版信息
Mov Disord. 2009 Dec 15;24(16):2404-7. doi: 10.1002/mds.22768.
Abstract
A clinical overlap between Parkinson's disease (PD) and essential tremor (ET) has prompted a discussion whether these conditions share common genetic susceptibility factors. Recently, the first genome-wide association study in ET revealed a significant association with a variant in the LINGO1 gene. LINGO1 has also been demonstrated to play a role in the survival of dopaminergic neurons in an animal model of PD, and therefore constitutes a potential candidate gene for PD. In this study, SNPs rs9652490, rs11856808, and rs7177008 of LINGO1 were genotyped in a total of 694 Austrian subjects (349 PD, 345 controls). No association could be found between genotype or allele counts and PD. Neither did a subgroup analysis in tremor-dominant patients with PD reveal a significant association. This study on LINGO1-variants in PD argues against a major role of LINGO1 gene variations for PD.
摘要
帕金森病（PD）和特发性震颤（ET）之间存在临床重叠，这促使人们讨论这些疾病是否具有共同的遗传易感性因素。最近，ET 的第一项全基因组关联研究显示与 LINGO1 基因中的变异显著相关。LINGO1 还在 PD 的动物模型中被证明对多巴胺能神经元的存活起作用，因此构成 PD 的潜在候选基因。在这项研究中，LINGO1 的 SNPs rs9652490、rs11856808 和 rs7177008 在总共 694 名奥地利受试者（349 名 PD，345 名对照）中进行了基因分型。基因型或等位基因计数与 PD 之间没有关联。在震颤为主的 PD 患者亚组分析中也没有发现显著相关性。这项关于 PD 中 LINGO1 变异的研究表明，LINGO1 基因变异对 PD 的作用不大。
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