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J Am Coll Cardiol. 2010 Feb 2;55(5):481-2. doi: 10.1016/j.jacc.2009.07.071.
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Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation.Rac1 诱导的结缔组织生长因子调节心房颤动中的连接蛋白 43 和 N-钙黏蛋白表达。
J Am Coll Cardiol. 2010 Feb 2;55(5):469-80. doi: 10.1016/j.jacc.2009.08.064.
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Angiotensin II activates signal transducers and activators of transcription 3 via Rac1 in the atrial tissue in permanent atrial fibrillation patients with rheumatic heart disease.在患有风湿性心脏病的永久性心房颤动患者的心房组织中，血管紧张素II通过Rac1激活信号转导和转录激活因子3。
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Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling.血管紧张素II通过Rac1在心房肌细胞和成纤维细胞中激活信号转导和转录激活因子3：对他汀类药物在心房结构重塑中治疗作用的启示。
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Elevated expression of connective tissue growth factor in human atrial fibrillation and angiotensin II-treated cardiomyocytes.结缔组织生长因子在人类心房颤动和血管紧张素 II 处理的心肌细胞中的高表达。
Circ J. 2011;75(7):1592-600. doi: 10.1253/circj.cj-10-0892. Epub 2011 May 17.
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Cardiovasc Pathol. 2010 Sep-Oct;19(5):e149-57. doi: 10.1016/j.carpath.2009.07.002. Epub 2009 Sep 10.
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Increased expression of connective tissue growth factor and transforming growth factor-beta-1 in atrial myocardium of patients with chronic atrial fibrillation.慢性心房颤动患者心房心肌中结缔组织生长因子和转化生长因子-β1表达增加。
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A Review of the Molecular Mechanisms Underlying Cardiac Fibrosis and Atrial Fibrillation.心脏纤维化和心房颤动潜在分子机制的综述
J Clin Med. 2021 Sep 27;10(19):4430. doi: 10.3390/jcm10194430.
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Low-dose green tea intake reduces incidence of atrial fibrillation in a Chinese population.低剂量饮用绿茶可降低中国人群心房颤动的发病率。
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本文引用的文献

1
Valsartan for prevention of recurrent atrial fibrillation.缬沙坦预防心房颤动复发
N Engl J Med. 2009 Apr 16;360(16):1606-17. doi: 10.1056/NEJMoa0805710.
2
Prevention of atrial fibrillation with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.使用3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂预防心房颤动
Circulation. 2008 Sep 16;118(12):1285-93. doi: 10.1161/CIRCULATIONAHA.107.760892.
3
Molecular genetics of atrial fibrillation.心房颤动的分子遗传学
J Am Coll Cardiol. 2008 Jul 22;52(4):241-50. doi: 10.1016/j.jacc.2008.02.072.
4
Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling.血管紧张素II通过Rac1在心房肌细胞和成纤维细胞中激活信号转导和转录激活因子3：对他汀类药物在心房结构重塑中治疗作用的启示。
Circulation. 2008 Jan 22;117(3):344-55. doi: 10.1161/CIRCULATIONAHA.107.695346. Epub 2008 Jan 2.
5
Role of left atrial size in risk stratification and prognosis of patients undergoing stress echocardiography.左心房大小在接受负荷超声心动图检查患者的危险分层及预后中的作用。
J Am Coll Cardiol. 2007 Sep 25;50(13):1254-62. doi: 10.1016/j.jacc.2007.06.025. Epub 2007 Sep 10.
6
Role of Rac1 GTPase activation in atrial fibrillation.Rac1 GTP酶激活在心房颤动中的作用。
J Am Coll Cardiol. 2007 Jul 24;50(4):359-67. doi: 10.1016/j.jacc.2007.03.041. Epub 2007 Jul 6.
7
Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic rats.瑞舒伐他汀，一种3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂，可降低Ren2转基因大鼠的心脏氧化应激和重塑。
Endocrinology. 2007 May;148(5):2181-8. doi: 10.1210/en.2006-1355. Epub 2007 Feb 22.
8
Left atrial volume predicts the risk of atrial fibrillation after cardiac surgery: a prospective study.左心房容积可预测心脏手术后房颤风险：一项前瞻性研究。
J Am Coll Cardiol. 2006 Aug 15;48(4):779-86. doi: 10.1016/j.jacc.2006.03.054. Epub 2006 Jul 25.
9
Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation.心房颤动中连接蛋白40基因（GJA5）的体细胞突变。
N Engl J Med. 2006 Jun 22;354(25):2677-88. doi: 10.1056/NEJMoa052800.
10
Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis.靶向敲除ROCK1通过抑制反应性纤维化保护心脏免受压力过载的影响。
FASEB J. 2006 May;20(7):916-25. doi: 10.1096/fj.05-5129com.

Rac1 and connective tissue growth factor. The missing link between atrial remodeling and the pathogenesis of atrial fibrillation?

作者信息

Liao James K

出版信息

J Am Coll Cardiol. 2010 Feb 2;55(5):481-2. doi: 10.1016/j.jacc.2009.07.071.

DOI:10.1016/j.jacc.2009.07.071
PMID:20117463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2848439/
Abstract
摘要