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低剂量饮用绿茶可降低中国人群心房颤动的发病率。

Low-dose green tea intake reduces incidence of atrial fibrillation in a Chinese population.

作者信息

Liu Dong-Chen, Yan Jian-Jun, Wang You-Nan, Wang Ze-Mu, Xie Zhi-Yong, Ma Yao, Yang Yang, Yang Li, Wang Lian-Sheng

机构信息

Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

出版信息

Oncotarget. 2016 Dec 20;7(51):85592-85602. doi: 10.18632/oncotarget.12243.

Abstract

The aim of the present study was to assessthe association between green tea intake and incidence of atrial fibrillation (AF) in a Chinese population. A total of 801 (mean age: 62 years; 56% male) subjects were enrolled: 401 AF patients and 400 controls. All subjects completed a questionnaire and the associations between their green tea drinking habits and incidence of AF were assessed using the odds ratio (OR) and binary logistic regression. After multivariate adjustment, green tea intake presented as a protective factor against the incidence of AF (OR: 0.349, 95% CI: 0.253-0.483, P < 0.001). The green tea protection showed downward trend with increasing green tea intake (P for the trend= 0.001). Low frequency, low concentration, short-term tea consumption was classified as low-dose green tea intake. Green tea intake decreased the incidence of both paroxysmal AF (OR: 0.307, 95% CI: 0.216-0.436, P < 0.001) and persistent AF (OR: 0.355, 95% CI: 0.261-0.482, P < 0.001) and may be associated with a decreased incidence of AF. This study suggests that low-dose green tea intake strongly protects against AF.

摘要

本研究旨在评估中国人群中绿茶摄入量与房颤(AF)发生率之间的关联。共纳入801名受试者(平均年龄:62岁;56%为男性):401名房颤患者和400名对照。所有受试者均完成一份问卷,并使用比值比(OR)和二元逻辑回归评估他们的绿茶饮用习惯与房颤发生率之间的关联。经过多变量调整后,绿茶摄入量是预防房颤发生的保护因素(OR:0.349,95%置信区间:0.253 - 0.483,P < 0.001)。绿茶的保护作用随着绿茶摄入量的增加呈下降趋势(趋势P值 = 0.001)。低频、低浓度、短期饮茶被归类为低剂量绿茶摄入。绿茶摄入降低了阵发性房颤(OR:0.307,95%置信区间:0.216 - 0.436,P < 0.001)和持续性房颤(OR:0.355,95%置信区间:0.261 - 0.482,P < 0.001)的发生率,可能与房颤发生率降低有关。本研究表明,低剂量绿茶摄入对房颤有很强的预防作用。

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