Division of Vascular Surgery, Stony Brook University Medical Center, Stony Brook, NY 11794-8191, USA.
J Vasc Surg. 2010 Jan;51(1):96-103. doi: 10.1016/j.jvs.2009.08.069.
The purpose of this study was to determine the prevalence, distribution, and extent of varicosities and focal dilatations in the saphenous trunks, their association with the sites of reflux, and their correlation with CEAP classes.
This prospective study included patients belonging to different CEAP classes (2-6) and a control group of age- and gender-matched healthy volunteers (group C). Color-flow duplex scan imaging was used to evaluate the entire venous system from groin to ankle for reflux and obstruction. Varicose segments and focal dilatations of the great and small saphenous veins (GSV and SSV) were recorded, and the diameters throughout the length of the saphenous trunks were measured. The presence of varicosities in the tributaries and accessory veins were documented.
From the 739 consecutive patients, 239 were excluded due to superficial venous thrombosis (SVT), deep venous thrombosis (DVT), both SVT and DVT, previous interventions, or C3-C6 presentation with no chronic venous disease (CVD). The included 500 patients (681 limbs) were divided into two groups based on CEAP class: group A (C2 + C3) and group B (C4-6). Group A had significantly more women than group B and a younger mean age (48 vs 56 years). Overall, GSV reflux (86%) was more prevalent than SSV reflux (17%), P < .0001. Saphenous trunk diameters, saphenofemoral junction (SFJ) and saphenopopliteal junction (SPJ) involvement were greater in group B, (P < .01). Group C had smaller saphenous diameters compared to group A in all locations (P < .05) but the malleoli. The prevalence of the saphenous varicose segments in both groups was small with the GSV in group B being the highest (4.3%) and the SSV in group A being the smallest (1.2%). Focal dilatations were significantly more prevalent than varicosities in the saphenous trunks (P < .0001). Varicosities of tributaries and accessory veins were more prevalent than those of saphenous trunks (P < .0001). The mean length of varicose segments in the saphenous trunks was short (3.8 cm, range, 2.1-6.4 for group A vs 4.1 cm, range, 2.3-8.3 for group B, P = .09).
A novel definition for varicosities in the saphenous trunks was established. Using this definition, it was determined that focal dilatations are far more common than varicosities. Because both of these entities are more prevalent in the accessory saphenous veins and tributaries, and CEAP class correlates positively with the extent of reflux and saphenous trunk diameter, studies on earlier interventions are warranted to prevent CVD progression.
本研究旨在确定隐静脉主干中静脉曲张和局灶性扩张的流行率、分布和程度,以及它们与反流部位的关系,并与 CEAP 分级相关联。
这项前瞻性研究纳入了不同 CEAP 分级(2-6 级)的患者和年龄、性别匹配的健康志愿者对照组(C 组)。采用彩色血流双功能超声扫描评估腹股沟至踝部的整个静脉系统,以评估反流和阻塞情况。记录大隐静脉(GSV)和小隐静脉(SSV)的静脉曲张段和局灶性扩张段,并测量隐静脉主干全长的直径。记录属支和辅助静脉中静脉曲张的存在情况。
在 739 例连续患者中,有 239 例因浅静脉血栓形成(SVT)、深静脉血栓形成(DVT)、SVT 和 DVT 并存、既往介入治疗或 C3-C6 级无慢性静脉疾病(CVD)而被排除。纳入的 500 例(681 条肢体)患者根据 CEAP 分级分为两组:A 组(C2+C3)和 B 组(C4-6)。A 组女性明显多于 B 组,平均年龄较小(48 岁比 56 岁)。总体而言,GSV 反流(86%)比 SSV 反流(17%)更为常见,P<0.0001。B 组隐静脉主干直径、隐股交界处(SFJ)和隐腘静脉交界处(SPJ)受累程度更大,(P<0.01)。与 A 组相比,C 组在所有部位的隐静脉主干直径均较小(P<0.05),但外踝除外。两组中隐静脉静脉曲张段的发生率均较小,B 组 GSV 最高(4.3%),A 组 SSV 最低(1.2%)。与隐静脉主干相比,局灶性扩张更为常见(P<0.0001)。隐静脉主干的静脉曲张比属支和辅助静脉更常见(P<0.0001)。隐静脉主干静脉曲张段的平均长度较短(A 组为 3.8cm,范围为 2.1-6.4cm;B 组为 4.1cm,范围为 2.3-8.3cm,P=0.09)。
本研究建立了隐静脉主干静脉曲张的新定义。使用该定义,确定局灶性扩张比静脉曲张更为常见。由于这些实体在辅助隐静脉和属支中更为常见,并且 CEAP 分级与反流程度和隐静脉主干直径呈正相关,因此需要进行早期干预研究,以防止 CVD 进展。