Department of Pediatrics, University of Tartu, Tartu, Estonia.
Pediatr Neurol. 2010 Feb;42(2):93-100. doi: 10.1016/j.pediatrneurol.2009.08.009.
We investigated the incidence and 30-day case-fatality of childhood stroke in Estonia, and clinical signs and risk factors of childhood stroke. A retrospective (1995-2003) and prospective study (2004-2006) of childhood stroke (arterial ischemic, hemorrhagic, and sinovenous thrombosis) and transient ischemic attack was conducted. Stroke-incidence calculation was based on the prospective study. Clinical diagnoses of stroke were confirmed by neuroradiology. The incidence rate of childhood stroke in Estonia was 2.73/100,000 person-years for children aged 30 days to 18 years: 1.61/100,000 for arterial ischemic stroke, 0.87/100,000 for hemorrhagic stroke, 0.25/100,000 for sinovenous thrombosis, and 0.37/100,000 for transient ischemic attack. No arterial ischemic stroke patients died within 30 days, but case-fatality for intracerebral hemorrhage was 46%. Focal signs occurred in 100% of arterial ischemic strokes and 64% of intracerebral hemorrhage cases. Risk factors were identified in 35/48 (73%) children with cerebrovascular attacks. Six children with arterial ischemic stroke (6/24, 25%) manifested more than one risk factor. The incidence rate of childhood stroke in Estonia is similar to that in earlier data.
我们研究了爱沙尼亚儿童中风的发病率和 30 天病死率，以及儿童中风的临床症状和危险因素。我们进行了一项回顾性（1995-2003 年）和前瞻性研究（2004-2006 年），研究对象为儿童中风（动脉缺血性、出血性和静脉窦血栓形成）和短暂性脑缺血发作。中风发病率的计算基于前瞻性研究。中风的临床诊断通过神经影像学确认。爱沙尼亚儿童中风的发病率为 30 天至 18 岁儿童每 10 万人年 2.73 例：动脉缺血性中风 1.61/100,000 例，出血性中风 0.87/100,000 例，静脉窦血栓形成 0.25/100,000 例，短暂性脑缺血发作 0.37/100,000 例。没有动脉缺血性中风患者在 30 天内死亡，但脑出血的病死率为 46%。100%的动脉缺血性中风和 64%的脑出血患者出现局灶性体征。在 48 例（73%）脑血管病患儿中发现了危险因素。6 例动脉缺血性中风患儿（6/24，25%）表现出多种危险因素。爱沙尼亚儿童中风的发病率与早期数据相似。
