Ilves Pilvi, Tomberg Tiiu, Kepler Joosep, Laugesaar Rael, Kaldoja Mari-Liis, Kepler Kalle, Kolk Anneli
Radiology Clinic of Tartu University Hospital, Department of Radiology, University of Tartu, Tartu, Estonia
Radiology Clinic of Tartu University Hospital and Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia.
J Child Neurol. 2014 Jun;29(6):756-64. doi: 10.1177/0883073813489350. Epub 2013 Jun 6.
Plasticity of language function after brain damage can depend on maturation of the brain. Children with left-hemisphere perinatal (n = 7) or childhood stroke (n = 5) and 12 controls were investigated using functional magnetic resonance imaging. The verb generation and the sentence comprehension tasks were employed to activate the expressive and receptive language areas, respectively. Weighted laterality indices were calculated and correlated with results assessed by neuropsychological test battery. Compared to controls, children with childhood stroke showed significantly lower mean scores for the expressive (P < .05) and receptive (P = .05) language tests. On functional magnetic resonance imaging they showed left-side cortical activation, as did controls. Perinatal stroke patients showed atypical right-side or bilateral language lateralization during both tasks. Negative correlation for stroke patients was found between scores for expressive language tests and laterality index during the verb generation task. (Re)organization of language function differs in children with perinatal and childhood stroke and correlates with neurocognitive performance.
脑损伤后语言功能的可塑性可能取决于大脑的成熟度。对7名左半球围产期脑损伤儿童、5名儿童期中风儿童以及12名对照儿童进行了功能磁共振成像研究。分别采用动词生成任务和句子理解任务来激活表达性和接受性语言区域。计算加权偏侧指数，并将其与神经心理测试组评估的结果进行相关性分析。与对照组相比，儿童期中风儿童在表达性语言测试（P < .05）和接受性语言测试（P = .05）中的平均得分显著更低。在功能磁共振成像中，他们与对照组一样表现出左侧皮质激活。围产期中风患者在两项任务中均表现出非典型的右侧或双侧语言偏侧化。在动词生成任务中，中风患者的表达性语言测试得分与偏侧指数之间存在负相关。围产期和儿童期中风儿童的语言功能（重新）组织存在差异，且与神经认知表现相关。
