Service de Génétique Histologie Biologie du Développement et de la Reproduction (CECOS Franche-Comté Bourgogne), Centre Hospitalier Universitaire, Université de Franche-Comté, Besançon, France.
Fertil Steril. 2010 May 1;93(7):2413.e15-9. doi: 10.1016/j.fertnstert.2009.12.022. Epub 2010 Feb 1.
To report the first case of restoration of ovarian activity and live birth after cryopreserved ovarian tissue autograft in a patient without cancer treated by allogeneic bone marrow transplantation.
Case report.
University hospital.
PATIENT(S): One woman with homozygous sickle cell anemia.
INTERVENTION(S): An orthotopic autotransplantation of ovarian cortical strips was performed after freeze-thawing.
MAIN OUTCOME MEASURE(S): Cryopreservation of ovarian tissue, bone marrow transplantation, ovarian autograft, and restoration of ovarian function.
RESULT(S): In autumn 2005, biopsy samples of ovarian tissue were cryopreserved before chemotherapy followed by bone marrow transplantation. In spring 2008, because the patient had been menopausal for 2.5 years as a result of the conditioning therapy, an orthotopic autotransplantation of thawed ovarian cortex was performed. The patient conceived spontaneously in a natural cycle in autumn 2008, and delivered a healthy female child in June 2009.
CONCLUSION(S): Cryopreservation of ovarian tissue with subsequent autotransplantation is an emerging procedure for preserving the fertility of young patients with a high risk of premature ovarian failure (POF) resulting from gonadotoxic treatment. This case opens up new perspectives in cases of nonmalignant diseases.
报告首例异体骨髓移植治疗的非癌症患者冷冻保存卵巢组织自体移植后卵巢功能恢复和活产的病例。
病例报告。
大学医院。
一名患有纯合镰状细胞贫血的女性。
冷冻-解冻后进行卵巢皮质条的原位自体移植。
卵巢组织的冷冻保存、骨髓移植、卵巢自体移植和卵巢功能的恢复。
2005 年秋季，患者在化疗前和骨髓移植前进行了卵巢组织活检样本的冷冻保存。2008 年春季，由于预处理治疗导致患者已经绝经 2.5 年，因此进行了解冻卵巢皮质的原位自体移植。2008 年秋季，患者自然周期妊娠，并于 2009 年 6 月分娩一健康女婴。
冷冻保存卵巢组织并随后进行自体移植是一种新兴的方法，可用于保存因性腺毒性治疗而有发生过早卵巢功能衰竭（POF）风险的年轻患者的生育能力。该病例为非恶性疾病开辟了新的前景。
